三种血浆胆汁酸的组合作为精神分裂症的潜在生物标志物。
A combination of three plasma bile acids as a putative biomarker for schizophrenia.
机构信息
Shanghai Key Laboratory of Compound Chinese Medicines, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Shanghai R&D Center for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
出版信息
Acta Neuropsychiatr. 2021 Feb;33(1):51-54. doi: 10.1017/neu.2020.42. Epub 2020 Nov 23.
The aim of the present study is to determine whether plasma bile acids (BAs) could be used as an auxiliary diagnostic biomarker to distinguish patients with schizophrenia from healthy controls. Seventeen different BAs were quantitatively measured in plasma of 12 healthy participants and 12 patients with schizophrenia. Then, the data were subjected to correlation and linear discriminant analysis (LDA). The concentrations of cholic acid (CA), taurochenodeoxycholic acid (TCDCA) and taurodeoxycholic acid (TDCA) were significantly decreased in plasma of the schizophrenia patients. Correlation analysis showed the concentrations of CA, TCDCA and TDCA were negatively correlated with schizophrenia. In addition, LDA demonstrated that combination of CA, TCDCA and TDCA with a classification formula could predict correctly classified cases and the accuracy of prediction was up to 95.83%. Combination of the three BAs may be useful to diagnose schizophrenia in plasma samples.
本研究旨在确定血浆胆汁酸（BAs）是否可用作辅助诊断生物标志物，以区分精神分裂症患者与健康对照者。我们定量检测了 12 名健康参与者和 12 名精神分裂症患者的血浆中的 17 种不同的 BAs，然后对数据进行了相关性和线性判别分析（LDA）。研究发现，精神分裂症患者的血浆中胆酸（CA）、牛磺鹅脱氧胆酸（TCDCA）和牛磺脱氧胆酸（TDCA）的浓度显著降低。相关性分析表明，CA、TCDCA 和 TDCA 的浓度与精神分裂症呈负相关。此外，LDA 表明，CA、TCDCA 和 TDCA 的组合与分类公式相结合，可以正确预测分类病例，预测准确率高达 95.83%。这三种 BAs 的组合可能有助于在血浆样本中诊断精神分裂症。
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