Fu Chuanwen, Zhang Xuehui, Qian Ying, Wang Ximei, Chen Xinqiang, Zeng Jia, Zhang Nichang, Wang Liming, Li Mingsong, Li Zhengxu, Zhang Teng, Feng Yuemei, Yin Jianzhong
Yunnan Provincial Key Laboratory of Public Health and Biosafety & School of Public Health, Kunming Medical University, Kunming, China.
School of Economics and Management, Baoshan University, Baoshan, China.
Eur Arch Psychiatry Clin Neurosci. 2025 Sep 13. doi: 10.1007/s00406-025-02103-y.
People living with schizophrenia (PLWS) have a reduced life expectancy with cardiovascular disease (CVD) as a major contributor. This article reviews the existing populations and animal studies and summarizes that reduced abundance of Lachnospiraceae, Bacteroides, Faecalibacterium, Ruminococcus, Roseburia, Bifidobacterium, Lactobacillus, Akkermansia, Rikenellaceae and increased abundance of Prevotella, Clostridium, Escherichia in PLWS is one of the probable reasons for the increased risk of CVD prevalence in PLWS by affecting the metabolism of substances related to the development of Schizophrenia (SCZ) and CVD.
精神分裂症患者（PLWS）的预期寿命缩短，心血管疾病（CVD）是主要原因。本文综述了现有的人群和动物研究，并总结出PLWS中毛螺菌科、拟杆菌属、粪杆菌属、瘤胃球菌属、罗氏菌属、双歧杆菌属、乳酸杆菌属、阿克曼菌属、理研菌科的丰度降低，而普雷沃菌属、梭菌属、大肠杆菌的丰度增加，这是PLWS中CVD患病率增加风险的可能原因之一，因为它影响了与精神分裂症（SCZ）和CVD发展相关物质的代谢。
