Zhu Yuanrun, Zheng Peidong, Lin Yajun, Wang Juehan, You Wendong, Wang Yadong, Zheng Huiqing, Wen Liang, Yang Xiaofeng
The First Affiliated Hospital, School of Medicine, Zhejiang University, 1367 West Wenyi Rd., Hangzhou, Zhejiang Province 310003, China.
Zhejiang University School of Medicine, 866 Yuhangtang Rd., Hangzhou, Zhejiang Province 310003, China.
J Clin Biochem Nutr. 2023 Jul;73(1):97-102. doi: 10.3164/jcbn.23-10. Epub 2023 Jun 13.
Traumatic brain injury is one of the major causes of morbidity and mortality worldwide. With the development of bile acids as a potential treatment, to identify the influence of traumatic brain injury on bile acid metabolism shows growing importance. This present study did a preliminary exploration of the bile acid profile alteration among traumatic brain injury patients. In total, 14 patients and 7 healthy volunteers were enrolled. The bile acid profile of the blood samples were detected by an Ultra-performance Liquid Chromatography Mass Spectrometer/Mass Spectrometer system. It was found that 6 bile acids were statistically decreased in traumatic brain injury patients comparing with healthy volunteers: glycocholic acid (median level 44.4 ng/ml vs 98.7 ng/ml, = 0.003), taurocholic acid (median level 10.9 ng/ml vs 19.5 ng/ml, = 0.006), glycoursodeoxycholic acid (median level 17.4 ng/ml vs 71.4 ng/ml, = 0.001), ursodeoxycholic acid (median level <1 ng/ml vs 32.4 ng/ml, = 0.002), taurochenodeoxycholic acid (median level <1 ng/ml vs 53.6 ng/ml, = 0.003) and glycochenodeoxycholic acid (GCDCA, median level 160 ng/ml vs 364 ng/ml, <0.001). In conclusion, traumatic brain injury events are able to induce bile acid metabolism alteration in plasma and might cause reduction in glycocholic, taurocholic, glycoursodeoxycholic, ursodeoxycholic, taurochenodeoxycholic and glycochenodeoxycholic acid levels.
创伤性脑损伤是全球发病和死亡的主要原因之一。随着胆汁酸作为一种潜在治疗方法的发展，确定创伤性脑损伤对胆汁酸代谢的影响显得越来越重要。本研究对创伤性脑损伤患者胆汁酸谱的改变进行了初步探索。总共招募了14名患者和7名健康志愿者。通过超高效液相色谱质谱仪/质谱仪系统检测血样的胆汁酸谱。结果发现，与健康志愿者相比，创伤性脑损伤患者中有6种胆汁酸在统计学上有所下降：甘氨胆酸（中位水平44.4 ng/ml对98.7 ng/ml，P = 0.003）、牛磺胆酸（中位水平10.9 ng/ml对19.5 ng/ml，P = 0.006）、甘氨熊去氧胆酸（中位水平17.4 ng/ml对71.4 ng/ml，P = 0.001）、熊去氧胆酸（中位水平<1 ng/ml对32.4 ng/ml，P = 0.002）、牛磺鹅去氧胆酸（中位水平<1 ng/ml对53.6 ng/ml，P = 0.003）和甘氨鹅去氧胆酸（GCDCA，中位水平160 ng/ml对364 ng/ml，P<0.0作01）。总之，创伤性脑损伤事件能够诱导血浆中胆汁酸代谢改变，并可能导致甘氨胆酸、牛磺胆酸、甘氨熊去氧胆酸、熊去氧胆酸、牛磺鹅去氧胆酸和甘氨鹅去氧胆酸水平降低。
