College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
Sinsegye Animal Hospital, Daegu, Republic of Korea.
J Comp Pathol. 2020 Oct;180:1-4. doi: 10.1016/j.jcpa.2020.07.010. Epub 2020 Sep 8.
Myofibromas are mesenchymal tumours of myofibroblastic origin that occur in solitary or multicentric forms. Solitary benign myofibromas mainly occur on the head and neck, especially in the subcutaneous region. They rarely occur in visceral organs in humans, but visceral myofibroma has not been reported in animals. We now report a case of testicular myofibroma in a 6-year-old rabbit in which orchiectomy revealed an enlarged testis with a multinodular surface. The cut surface of the testis showed a thick, homogeneous white-yellow mass surrounding the testicular parenchyma. Histopathologically, the mass was composed of collagen and eosinophilic fascicles of spindle cells that were immunopositive for α-smooth muscle actin but not desmin, S-100 or von Willebrand factor. These features distinguished the myofibroma from other spindle cell tumours. To the best of our knowledge, this is the first report of solitary testicular myofibroma in any animal species.
肌纤维瘤是由肌纤维母细胞起源的间叶性肿瘤，有单发或多发两种形式。单发良性肌纤维瘤主要发生于头颈部，尤其好发于皮下组织。它们在人类内脏器官中很少见，但在动物内脏中尚未有肌纤维瘤的报道。我们现在报告一例 6 岁家兔的睾丸肌纤维瘤，经睾丸切除术显示睾丸肿大，表面呈多结节状。睾丸切面显示厚而均匀的黄白色肿块环绕睾丸实质。组织病理学上，肿块由胶原和嗜酸性束状的梭形细胞组成，α-平滑肌肌动蛋白免疫阳性，但结蛋白、S-100 或血管性血友病因子阴性。这些特征将肌纤维瘤与其他梭形细胞瘤区分开来。据我们所知，这是首例在任何动物物种中报道的单发睾丸肌纤维瘤。
