Sunshine Coast Mind and Neuroscience - Thompson Institute, University of the Sunshine Coast, Birtinya, QLD, Australia.
Sunshine Coast Mind and Neuroscience - Thompson Institute, University of the Sunshine Coast, Birtinya, QLD, Australia.
J Clin Neurosci. 2020 Nov;81:167-172. doi: 10.1016/j.jocn.2020.09.034. Epub 2020 Oct 10.
The aim of this study was to determine the effect of age on the relationship between cerebrovascular function and the neural bases of sustained attention. Twenty-seven healthy young adults (aged 18-30 years) and 24 older adults (60-75 years) underwent assessments of cerebrovascular function and sustained attention. Blood flow velocity of the middle cerebral artery was assessed via Transcranial Doppler Ultrasound, during seated rest, in response to hypocapnic breathing (cerebrovascular reactivity) and during a repeated sit-to-stand procedure (pressure-flow response). Attentional processing was assessed using the N2 and P3 components of the event-related potential during a two-tone auditory oddball task. Poorer pressure-flow responses were significantly associated with reductions in N2 and P3 amplitude in the old group (b = -0.50, p = .029 and b = -0.46, p = .045), but not the young group. These results suggest that alterations in the brain's capacity to combat reductions in perfusion pressure are associated with age-related differences in attentional processing, supporting the hypothesis that cerebrovascular hemodynamic disturbances play a role in age-related cognitive decline.
这项研究的目的是确定年龄对脑血管功能与持续注意力神经基础之间关系的影响。27 名健康的年轻成年人（18-30 岁）和 24 名老年人（60-75 岁）接受了脑血管功能和持续注意力评估。通过经颅多普勒超声，在坐姿休息时、对低碳酸呼吸的反应时（脑血管反应性）以及在重复坐站过程中（压力-流量反应）评估大脑中动脉的血流速度。使用事件相关电位中的 N2 和 P3 成分，在双音听觉Oddball 任务中评估注意力处理。压力-流量反应较差与老年组 N2 和 P3 振幅降低显著相关（b=-0.50，p=.029 和 b=-0.46，p=.045），而在年轻组中则没有。这些结果表明，大脑对抗灌注压降低的能力的改变与注意力处理的年龄相关差异有关，支持了脑血管血液动力学紊乱在与年龄相关的认知衰退中起作用的假说。
