Department of Oncology and Hemato-Oncology, Via Festa del Perdono 7, Milan 20122, Italy; IRCCS Istituto Ortopedico Galeazzi, Neurochirurgia Oncologica, Milan, Italy.
Department of Oncology and Hemato-Oncology, Via Festa del Perdono 7, Milan 20122, Italy; IRCCS Istituto Ortopedico Galeazzi, Neurochirurgia Oncologica, Milan, Italy.
Neurosurg Clin N Am. 2021 Jan;32(1):137-148. doi: 10.1016/j.nec.2020.08.008. Epub 2020 Nov 5.
The management of glioblastoma in the elderly population represents a field of growing interest owing a longer life expectancy. In this age group, more than in the young adult, biological age is much more important than chronologic one. The date of birth should not exclude a priori access of treatments. Maximal safe resection is proved to be the first option when performance status and general health is good. Adjuvant therapy and decision about management of recurrence should be choose in a multidisciplinary group according to performance of the patients and O-methylguanine-DNA methyl-transferase methylation.
老年人胶质母细胞瘤的管理是一个日益受到关注的领域，这是由于预期寿命的延长。在这个年龄组中，生物年龄比实际年龄重要得多，比年轻人更为重要。出生日期不应预先排除治疗的机会。在身体状况和整体健康状况良好的情况下，最大限度地安全切除被证明是首选治疗方案。辅助治疗和复发管理决策应根据患者的表现和 O6-甲基鸟嘌呤-DNA 甲基转移酶甲基化情况，在多学科小组中选择。
