神经调节在神经疾病中的进展与未来方向

Advances and Future Directions of Neuromodulation in Neurologic Disorders.

机构信息

The Fixel Institute for Neurological Diseases, Department of Neurology, The University of Florida, 3009 Williston Road, Gainesville, FL 32608, USA.

出版信息

Neurol Clin. 2021 Feb;39(1):71-85. doi: 10.1016/j.ncl.2020.09.004. Epub 2020 Nov 7.

DOI:10.1016/j.ncl.2020.09.004

PMID:33223090

Abstract

"Deep brain stimulation is a safe and effective therapy for the management of a variety of neurologic conditions with Food and Drug Administration or humanitarian exception approval for Parkinson disease, dystonia, tremor, and obsessive-compulsive disorder. Advances in neurophysiology, neuroimaging, and technology have driven increasing interest in the potential benefits of neurostimulation in other neuropsychiatric conditions including dementia, depression, pain, Tourette syndrome, and epilepsy, among others. New anatomic or combined targets are being investigated in these conditions to improve symptoms refractory to medications or standard stimulation."

摘要

脑深部电刺激是一种安全有效的治疗方法，可用于管理各种神经系统疾病，已获得美国食品药品监督管理局或人道主义豁免批准，可用于治疗帕金森病、肌张力障碍、震颤和强迫症。神经生理学、神经影像学和技术的进步，推动了人们对神经刺激在其他神经精神疾病（包括痴呆、抑郁、疼痛、妥瑞氏症和癫痫等）中潜在益处的兴趣日益增加。针对这些疾病，新的解剖或联合靶点正在被研究，以改善对药物或标准刺激有抗性的症状。