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合成作为抗新冠病毒剂的潜在新型β-取代-2-喹啉基乙酰肼席夫碱

Synthesis of potentially new schiff bases of -substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents.

作者信息

Alshammari Mohammed B, Ramadan Mohamed, Aly Ashraf A, El-Sheref Essmat M, Bakht Md Afroz, Ibrahim Mahmoud A A, Shawky Ahmed M

机构信息

Chemistry Department, College of Sciences and Humanities, Prince Sattam bin Abdulaziz University, P.O. Box 83, Al-Kharij 11942, Saudi Arabia.

Department of Organic Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Egypt.

出版信息

J Mol Struct. 2021 Apr 15;1230:129649. doi: 10.1016/j.molstruc.2020.129649. Epub 2020 Nov 16.

DOI:10.1016/j.molstruc.2020.129649
PMID:33223566
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7668221/
Abstract

We report herein a new series of synthesized -substituted-2-quinolonylacetohydrazides aiming to evaluate their activity towards SARS-CoV-2. The structures of the obtained products were fully confirmed by NMR, mass, IR spectra and elemental analysis as well. Molecular docking calculations showed that most of the tested compounds possessed good binding affinity to the SARS-CoV-2 main protease (M) comparable to.

摘要

我们在此报告一系列新的合成的 - 取代 -2 - 喹啉基乙酰肼，旨在评估它们对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的活性。所获得产物的结构通过核磁共振（NMR）、质谱、红外光谱以及元素分析得到了充分确认。分子对接计算表明，大多数测试化合物对SARS-CoV-2主要蛋白酶（M）具有与……相当的良好结合亲和力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/24048a51f83a/gr7a_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/54e8677a87ed/fx1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/73d030b50c49/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/df45ae9319c8/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/c1e81630c200/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/1302f506fa29/sc1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/d0dc5e1ef5be/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/a4b8e518312c/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/e5e31865a382/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/24048a51f83a/gr7a_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/54e8677a87ed/fx1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/73d030b50c49/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/df45ae9319c8/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/c1e81630c200/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/1302f506fa29/sc1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/d0dc5e1ef5be/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/a4b8e518312c/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/e5e31865a382/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/7668221/24048a51f83a/gr7a_lrg.jpg

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