Saroja Aralikatte O, Thorat Ninad N, Naik Karkal R
Department of Neurology, Jawaharlal Nehru Medical College, Nehru Nagar, Belagavi, Karnataka, India.
Ann Indian Acad Neurol. 2020 Jul-Aug;23(4):487-490. doi: 10.4103/aian.AIAN_191_19. Epub 2019 Jun 9.
Cerebral venous sinus thrombosis (CVST) is an important cause of stroke in young and has a favorable outcome. Long-term sequelae of CVST include motor disability, cognitive impairment, depression, anxiety, fatigue, impaired employment and poor quality of life.
To evaluate depression and quality of life after CVST.
Patients who completed at least 1 year after discharge were recruited for this cross-sectional observational study from our CVST cohort. Quality of life was assessed using Stroke-Adapted Sickness Impact Profile (SA-SIP 30) and depression using Hamilton Depression scale (HAM-D).
A total of 100 patients (60 men and 40 women) were included in the study. Their age ranged from 14 to 60 years (34.97 ± 10.06). The interval from discharge to assessment of quality of life was 2.2 ± 1.6 years. In all, 98% of patients had good modified Rankin score at follow-up. SA-SIP 30 did not reveal any functional disability for physical functioning. Seven had impairment for psychosocial domain despite having good modified Rankin scores. Thirty patients had depression. Patients with higher mRS at discharge had increased presence of depression. Quality-of-life scores did not correlate with presence of seizure, headache, infarction and sinuses involved.
This is the first Indian study demonstrating depression in patients with CVST and use of SA-SIP to assess quality of life in them. Occurrence of depression in CVST is as high as in arterial strokes.
脑静脉窦血栓形成（CVST）是年轻人中风的重要原因，且预后良好。CVST的长期后遗症包括运动功能障碍、认知障碍、抑郁、焦虑、疲劳、就业受限和生活质量差。
评估CVST后的抑郁情况和生活质量。
从我们的CVST队列中招募出院后至少满1年的患者进行这项横断面观察性研究。使用卒中适应性疾病影响量表（SA-SIP 30）评估生活质量，使用汉密尔顿抑郁量表（HAM-D）评估抑郁情况。
共有100名患者（60名男性和40名女性）纳入研究。他们的年龄在14至60岁之间（34.97±10.06）。从出院到生活质量评估的时间间隔为2.2±1.6年。总体而言，98%的患者在随访时改良Rankin评分良好。SA-SIP 30未显示身体功能方面有任何功能障碍。尽管改良Rankin评分良好，但有7名患者在心理社会领域存在损害。30名患者有抑郁症状。出院时mRS较高的患者抑郁症状更为常见。生活质量评分与癫痫发作、头痛、梗死和受累静脉窦的存在无关。
这是第一项印度研究，证明了CVST患者存在抑郁，并使用SA-SIP评估他们的生活质量。CVST中抑郁的发生率与动脉性中风一样高。
