Patwardhan Ameya, Gupta Manisha, Philip Mariamma, Rangarajan Anush, Joshi Tarachand, Alladi Suvarna, Kulkarni Girish B, Ramakrishnan Subasree
Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India.
Department of Biostatistics, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India.
Ann Indian Acad Neurol. 2024 Jan-Feb;27(1):34-39. doi: 10.4103/aian.aian_792_23. Epub 2024 Feb 1.
Deep cerebral venous thrombosis (DCVT) can have long-term functional and cognitive sequelae. Although literature exists on cognitive impairment after arterial stroke, cognitive sequelae after cerebral venous thrombosis (CVT) are much less studied.
Clinical records of 29 patients diagnosed with DCVT were reviewed. The Modified Telephonic Interview for Cognitive Status (TICS-M) was adapted and validated in the regional language (Kannada) and applied to 18 patients with DCVT, at a mean follow-up duration of 5.32 years. Screening for depression was done via telephonic Patient Health Questionnaire-9 (PHQ-9)-Kannada version, and functional status was screened by applying the modified Rankin Scale (mRS).
DCVT had a mortality rate of 10.34% due to acute complications. mRS scores of 0-1 were achieved at follow-up in all patients who survived. Receiver operating characteristic (ROC) analysis revealed a cutoff of ≤44.5 (maximum score of 49) for the diagnosis of cognitive impairment via TICS-M (Kannada version) in DCVT patients. Evidence of cognitive dysfunction was seen in eight patients (42.10%), and three patients (16.66%) had evidence of depression.
Survivors of acute DCVT can potentially have long-term cognitive sequelae. Screening for cognitive dysfunction, depression, and functional status can be effectively done using telephonically applied scales that are adapted to the local language. Neuropsychological evaluation and early cognitive rehabilitation can be initiated for patients in whom deficits are identified on cognitive screening.
大脑深静脉血栓形成（DCVT）可导致长期的功能和认知后遗症。虽然有关于动脉性卒中后认知障碍的文献，但关于脑静脉血栓形成（CVT）后的认知后遗症的研究要少得多。
回顾了29例诊断为DCVT的患者的临床记录。对改良的认知状态电话访谈（TICS-M）进行了改编，并在当地语言（卡纳达语）中进行了验证，应用于18例DCVT患者，平均随访时间为5.32年。通过电话患者健康问卷-9（PHQ-9）卡纳达语版本进行抑郁筛查，并应用改良Rankin量表（mRS）筛查功能状态。
DCVT因急性并发症的死亡率为10.34%。所有存活患者在随访时mRS评分均达到0-1分。受试者工作特征（ROC）分析显示，DCVT患者通过TICS-M（卡纳达语版本）诊断认知障碍的临界值为≤44.5（满分49分）。8例患者（42.10%）有认知功能障碍的证据，3例患者（16.66%）有抑郁的证据。
急性DCVT幸存者可能有长期的认知后遗症。使用适用于当地语言的电话应用量表可以有效地筛查认知功能障碍、抑郁和功能状态。对于在认知筛查中发现有缺陷的患者，可以启动神经心理学评估和早期认知康复。
