Uzeloto Juliana Souza, de Toledo-Arruda Alessandra Choqueta, Silva Bruna Spolador de Alencar, Golim Marjorie de Assis, Braz Aline Márcia Marques, de Lima Fabiano Francisco, Grigoletto Isis, Ramos Ercy Mara Cipulo
São Paulo State University (UNESP), Faculty of Science and Technology, Department of Physiotherapy, Postgraduate Program in Physiotherapy, Presidente Prudente, São Paulo, Brazil.
Department of Physiotherapy, Federal University of Rio de Janeiro, Rio De Janeiro, Brazil.
Int J Chron Obstruct Pulmon Dis. 2020 Nov 13;15:2931-2940. doi: 10.2147/COPD.S268955. eCollection 2020.
To evaluate the expressions of intracellular cytokines in CD4+ T lymphocytes and to investigate the correlation between biomarker expressions and clinical and functional characteristics of stable COPD patients.
Peripheral blood was collected from 36 COPD patients, and the expression of cytokines (IL-8, IL-13, IL-17, IL-6, IL-2, IL-10, and TNF-α) in T lymphocytes CD4 + was investigated. In addition, lung function, dyspnea symptoms, quality of life, vital signs, body composition, level of physical activity, peripheral muscle strength, and functional capacity were assessed.
Individuals with greater bronchial obstruction present a higher proportion of CD4 + IL-2 + lymphocytes compared to individuals with less severe bronchial obstruction. We found a positive correlation between the expression of the cytokines IL-13, IL-17, IL-6, IL-2, IL-10, and TNF-α in CD4+ T lymphocytes. In addition, we found a positive correlation between CD4+ IL-10+ T lymphocytes and lower limb muscle strength and a negative correlation between CD4+ IL-8+ T lymphocytes and peripheral oxygen saturation and steps per day.
Systemic CD4+IL-2+, IL-8+, and IL-10+ T lymphocytes presented a correlation with clinical characteristics and functional status in stable COPD.
评估CD4 + T淋巴细胞中细胞内细胞因子的表达，并研究生物标志物表达与稳定期慢性阻塞性肺疾病（COPD）患者临床及功能特征之间的相关性。
收集36例COPD患者的外周血，研究CD4 + T淋巴细胞中细胞因子（IL-8、IL-13、IL-17、IL-6、IL-2、IL-10和TNF-α）的表达。此外，评估肺功能、呼吸困难症状、生活质量、生命体征、身体组成、体力活动水平、外周肌肉力量和功能能力。
与支气管阻塞较轻的个体相比，支气管阻塞较重的个体中CD4 + IL-2 +淋巴细胞的比例更高。我们发现CD4 + T淋巴细胞中细胞因子IL-13、IL-17、IL-6、IL-2、IL-10和TNF-α的表达之间呈正相关。此外，我们发现CD4 + IL-10 + T淋巴细胞与下肢肌肉力量呈正相关，CD4 + IL-8 + T淋巴细胞与外周血氧饱和度及每日步数呈负相关。
全身性CD4 + IL-2 +、IL-8 +和IL-10 + T淋巴细胞与稳定期COPD的临床特征和功能状态相关。
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