Department of Respiratory Medicine, State University of Medicine and Pharmacy "Nicolae Testemitanu", Chisinau, Moldova.
Research Physician at Faculty of Medicine "Dr. Alberto Romo Caballero", Universidad Autonoma de Tamaulipas. Research Assistant II at Baylor College of Medicine, Houston, Texas. USA.
Pulmonology. 2020 Mar-Apr;26(2):95-100. doi: 10.1016/j.pulmoe.2019.10.006. Epub 2019 Nov 15.
Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous and multisystemic disease with progressive increasing morbidity and mortality. COPD is now widely accepted as a heterogeneous condition with multiple phenotypes and endotypes. This review will discuss the old and new concepts for the different types of COPD phenotypes, as well as the inclusion of them in current guidelines. Phenotypical approach to COPD is having huge impact on everyday practice and changed nonpharmacological and pharmacological management of COPD in last decade. However, phenotypical approach is small step to precision medicine in COPD management in the absence of big, specific and well-designed COPD trials with exact identification of phenotypes for more personalization of the treatment of COPD.
慢性阻塞性肺疾病（COPD）是一种异质性和多系统疾病，发病率和死亡率逐渐增加。COPD 现在被广泛认为是一种具有多种表型和内型的异质性疾病。这篇综述将讨论 COPD 不同表型的新概念和旧概念，以及它们在当前指南中的纳入情况。在过去十年中，COPD 的表型方法对日常实践产生了巨大影响，并改变了 COPD 的非药物和药物治疗。然而，在没有大型、具体和精心设计的 COPD 试验以及对表型的准确识别的情况下，表型方法只是 COPD 管理中迈向精准医学的一小步，无法实现 COPD 治疗的个体化。
