Wang Xiuli, Peng Hanlin, Huang Yaqian, Kong Wei, Cui Qinghua, Du Junbao, Jin Hongfang
Department of Pediatrics, Peking University First Hospital, Beijing, China.
Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China.
Front Cell Dev Biol. 2020 Nov 5;8:574706. doi: 10.3389/fcell.2020.574706. eCollection 2020.
The nuclear factor-kappa B (NF-κB) signaling pathway regulates a variety of biological functions in the body, and its abnormal activation contributes to the pathogenesis of many diseases, such as cardiovascular and respiratory diseases and cancers. Therefore, to ensure physiological homeostasis of body systems, this pathway is strictly regulated by IκBα transcription, IκBα synthesis, and the IκBα-dependent nuclear transport of NF-κB. Particularly, the post-translational modifications of IκBα including phosphorylation, ubiquitination, SUMOylation, glutathionylation and hydroxylation are crucial in the abovementioned regulatory process. Because of the importance of the NF-κB pathway in maintaining body homeostasis, understanding the post-translational modifications of IκBα can not only provide deeper insights into the regulation of NF-κB pathway but also contribute to the development of new drug targets and biomarkers for the diseases.
核因子-κB（NF-κB）信号通路调节身体中的多种生物学功能，其异常激活会导致许多疾病的发病机制，如心血管疾病、呼吸系统疾病和癌症。因此，为确保身体系统的生理稳态，该通路受到IκBα转录、IκBα合成以及NF-κB依赖IκBα的核转运的严格调控。特别是，IκBα的翻译后修饰，包括磷酸化、泛素化、SUMO化、谷胱甘肽化和羟基化，在上述调控过程中至关重要。由于NF-κB通路在维持身体稳态中的重要性，了解IκBα的翻译后修饰不仅可以更深入地了解NF-κB通路的调控，还有助于开发针对这些疾病的新药物靶点和生物标志物。
