Fisch College of Pharmacy, The University of Texas at Tyler , Tyler, TX, USA.
Expert Rev Clin Pharmacol. 2021 Jan;14(1):25-32. doi: 10.1080/17512433.2021.1855142. Epub 2020 Dec 1.
: Ketamine is being increasingly utilized in a variety of patient care settings, ranging from high acuity inpatient scenarios to the outpatient management of select mental health diagnoses. Postoperative patients are at an increased risk of developing a depressed state, and though ketamine's ability to improve mood is well documented in the literature, the relationship between perioperative ketamine and postoperative mood has not been fully elucidated. : The purpose of this review was to determine ketamine's ability to improve mood and depression scores in the perioperative setting. A comprehensive literature review was conducted using PubMed, MEDLINE, Scopus, ProQuest, Web of Science, and CINAHL using the following search terminology: 'ketamine' AND 'perioperative' OR 'surgery' AND 'mood' OR 'depression.' Seven clinical trials are evaluated in this review. : As the use of ketamine continues to expand, clinicians must be cognizant of the fact that many of its desired effects are likely to overlap. Patients outside of the perioperative setting may benefit from using ketamine as an analgesic or sedative, as appropriate, to mitigate mood and depression. Ketamine, when administered as an anesthetic in the perioperative setting, seemingly has effect on postoperative mood and depression. Further studies that are sufficient.
氯胺酮在各种患者护理环境中被越来越多地使用，从高 acuity 住院场景到选择精神健康诊断的门诊管理。术后患者出现抑郁状态的风险增加，尽管氯胺酮改善情绪的能力在文献中有充分记载，但围手术期氯胺酮与术后情绪之间的关系尚未完全阐明。本综述的目的是确定氯胺酮在围手术期改善情绪和抑郁评分的能力。使用 PubMed、MEDLINE、Scopus、ProQuest、Web of Science 和 CINAHL 进行了全面的文献综述，使用以下搜索术语：“氯胺酮”和“围手术期”或“手术”和“情绪”或“抑郁”。本综述评估了 7 项临床试验。随着氯胺酮的使用不断扩大，临床医生必须意识到，它的许多理想效果可能会重叠。围手术期以外的患者可能受益于将氯胺酮作为镇痛剂或镇静剂使用，以适当减轻情绪和抑郁。在围手术期作为麻醉剂给予氯胺酮，似乎对术后情绪和抑郁有影响。需要进一步充分的研究。
