Baltalı Sevim, Çiftçi Elvan, Baltalı Mehmet, Haliloğlu Murat, Ercan Ayşegül, Tunay Abdurrahman, Çelik Zeynep, Bozay Berna, Toptaş Mehmet
Department of Anesthesiology and Reanimation, Istanbul Training and Research Hospital, University of Health Sciences, Kasap İlyas Mah. Org. Abdurrahman Nafiz Gürman Cd. Fatih, İstanbul, 34098, Turkey.
Department of Psychiatry, Faculty of Medicine, Uskudar University, Saray, Site Yolu Cd No:27, Ümraniye, İstanbul, 34768, Turkey.
BMC Womens Health. 2025 Jul 30;25(1):380. doi: 10.1186/s12905-025-03920-y.
Several studies have shown that ketamine has an effect on mood and depression in the perioperative context; however, little is known about ketamine's effect on patients' emotional recovery after day-case surgery. We aimed to examine whether a single subanaesthetic dose of ketamine could improve acute mood in patients shortly following fractional curettage.
One hundred forty women from 202 consecutive fractional curettage patients were enrolled in this randomised, double-blind placebo-controlled single-centre trial. In addition to propofol and fentanyl anaesthesia, subjects were randomly assigned to receive a single dose of iv ketamine 0.5 mg/kg (ketamine group) or saline (control group). The main objective of this study was to analyse the total mood score between the two groups by using the Profile of Mood States (POMS) questionnaire performed before and 120 min after the procedure and to evaluate the impact of menstrual status and obesity on the total mood score among patients in the ketamine and control groups, as well as in the entire study group separately. Pain, haemodynamic changes, sedation levels, and adverse medication effects were all studied as secondary outcomes.
After surgery, both the ketamine and control groups showed a statistically significant decline in the total mood scores, although there were no apparent differences between the groups. Separate multiple linear regression analyses among ketamine group patients revealed that the presence of obesity was inversely related to total mood scores after surgery.
Our study showed that compared with the patients in the control group, a single subanaesthetic intravenous dosage of ketamine did not improve the total mood scores of patients in the ketamine group, as measured by the POMS questionnaire. On the other hand, obesity was an independent predictor of improvement in total mood scores among patients who received 0.5 mg/kg ketamine. Further studies are needed to evaluate the relationship between ketamine, obesity and patients' emotional recovery after surgery.
This randomised controlled double-blind trial was retrospectively registered at ClinicalTrials.gov (trial number: NCT05752110; date of registration: 02/03/2023).
多项研究表明，氯胺酮在围手术期对情绪和抑郁有影响；然而，关于氯胺酮对日间手术患者情绪恢复的影响知之甚少。我们旨在研究单次亚麻醉剂量的氯胺酮是否能改善刮宫术后患者的急性情绪。
从202例连续刮宫患者中选取140名女性参与这项随机、双盲、安慰剂对照的单中心试验。除丙泊酚和芬太尼麻醉外，受试者被随机分配接受单次静脉注射0.5mg/kg氯胺酮（氯胺酮组）或生理盐水（对照组）。本研究的主要目的是通过使用术前和术后120分钟进行的情绪状态剖面图（POMS）问卷分析两组之间的总情绪得分，并分别评估月经状态和肥胖对氯胺酮组和对照组以及整个研究组患者总情绪得分的影响。疼痛、血流动力学变化、镇静水平和药物不良反应均作为次要结果进行研究。
术后，氯胺酮组和对照组的总情绪得分均有统计学意义的下降，尽管两组之间没有明显差异。氯胺酮组患者的单独多元线性回归分析显示，肥胖的存在与术后总情绪得分呈负相关。
我们的研究表明，与对照组患者相比，单次亚麻醉静脉注射氯胺酮并未改善氯胺酮组患者通过POMS问卷测量的总情绪得分。另一方面，肥胖是接受0.5mg/kg氯胺酮患者总情绪得分改善的独立预测因素。需要进一步研究来评估氯胺酮、肥胖与术后患者情绪恢复之间的关系。
这项随机对照双盲试验在ClinicalTrials.gov上进行了回顾性注册（试验编号：NCT05752110；注册日期：2023年3月2日）。
