Pathology Department, Truman Medical Center, 2301 Holmes St, Kansas City, MO, 64108, USA.
Department of Oral and Craniofacial Sciences, University of Missouri-Kansas City School of Dentistry, 650 E 25th Street, Kansas City, MO, 64108, USA.
AIDS Res Ther. 2020 Nov 23;17(1):67. doi: 10.1186/s12981-020-00322-y.
Diagnosis of people living with HIV (PLHIV) is the first step toward achieving the new Fast Track Strategy to end AIDS by 2030: 95-95-95. However, reaching PLHIV is especially difficult in resource-limited settings such as the Democratic Republic of Congo (DRC), where reliable prevalence data is lacking. This study evaluated the prevalence of HIV in patients in the urban Kinshasa area.
Individuals seeking healthcare were tested for HIV between February 2017 and July 2018 at existing Kinshasa urban clinics. The study was conducted in two phases. Case finding was optimized in a pilot study phase using a modified cell phone-based Open\Data Kit (ODK) collection system. HIV prevalence was then determined from data obtained between March-July of 2018 from 8320 individuals over the age of 18 years receiving care at one of 47 clinics in Kinshasa.
The prevalence of HIV in our study was 11.0% (95% CI 10.3-11.6%) overall and 8.14% in the subset of N = 1240 participants who were healthy mothers seeking prenatal care. These results are in sharp contrast to President's Emergency Plan for AIDS Relief (PEPFAR) estimates of 2.86%, but are consistent with data from surrounding countries.
While this data is sub-national and reflects an urban healthcare setting, given the large population of Kinshasa and rapidly changing age demographics, the results suggest that HIV prevalence in the DRC is substantially higher than previously reported.
诊断艾滋病毒感染者(PLHIV)是实现 2030 年新的艾滋病快速通道战略的第一步:95-95-95。然而,在资源有限的环境中,如刚果民主共和国(DRC),找到 PLHIV 尤其困难,因为那里缺乏可靠的流行率数据。本研究评估了金沙萨市区患者的艾滋病毒流行率。
2017 年 2 月至 2018 年 7 月期间,在金沙萨现有的市区诊所对寻求医疗保健的个人进行艾滋病毒检测。该研究分两个阶段进行。在试点研究阶段,使用改良的基于手机的开放式数据套件(ODK)采集系统,优化了病例发现。然后,从 2018 年 3 月至 7 月期间,在金沙萨 47 家诊所中接受治疗的 8320 名年龄在 18 岁以上的个体中获得的数据,确定了艾滋病毒流行率。
本研究中,艾滋病毒的总体流行率为 11.0%(95%置信区间 10.3-11.6%),在 1240 名健康母亲接受产前保健的亚组中,流行率为 8.14%。这些结果与总统艾滋病紧急救援计划(PEPFAR)估计的 2.86%形成鲜明对比,但与周边国家的数据一致。
虽然这些数据是次国家级的,反映了城市医疗保健环境,但鉴于金沙萨庞大的人口和快速变化的年龄结构,结果表明,刚果民主共和国的艾滋病毒流行率远高于先前报告的水平。