Departments of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, School of Medicine, Inonu University, Malatya, Turkey.
Departments of Obstetrics and Gynecology, Malatya State Hospital, Malatya, Turkey.
J Obstet Gynaecol. 2021 Aug;41(6):946-950. doi: 10.1080/01443615.2020.1820459. Epub 2020 Nov 23.
The aim of this prospective study was to investigate whether there is a relationship between seminal plasma cadmium (Cd) and lead (Pb) levels and semen parameters in male partners of infertile couples. Two hundred fifty one (251) men recruited with no history of occupational exposure to toxic metals. After semen analysis, seminal Cd and Pb levels were measured using atomic absorption spectrometry. Cadmium levels in men with hypospermia was significantly higher than men with normal semen volume ( = .049). In contrast, there was no statistically significant difference in median seminal Pb levels between men with hypospermia and men with normal semen volume ( = .13). There was no statistically significant association between seminal plasma Cd and Pb levels sperm concentration, motility, morphology and total progressively motile sperm count. These findings suggest that environmental Cd exposure may contribute to low semen volume in male partners of infertile couples.IMPACT STATEMENT Toxic metals may adversely affect both male and female reproductive system. Seminal plasma cadmium levels in men with hypospermia were statistically significantly higher than men with normal semen volume. Patients should be informed about possible adverse effects of toxic metals.
本前瞻性研究旨在探讨不育夫妇男性伴侣精浆中镉（Cd）和铅（Pb）水平与精液参数之间是否存在关系。招募了 251 名无职业性接触有毒金属史的男性。精液分析后，采用原子吸收光谱法测定精浆 Cd 和 Pb 水平。少精子症男性的 Cd 水平明显高于正常精液量男性（= 0.049）。相反，少精子症男性和正常精液量男性的精浆 Pb 水平中位数无统计学差异（= 0.13）。精浆 Cd 和 Pb 水平与精子浓度、活力、形态和总前向运动精子计数之间无统计学关联。这些发现表明，环境 Cd 暴露可能导致不育夫妇男性伴侣精液量减少。
重要性声明：有毒金属可能对男性和女性的生殖系统都有不良影响。少精子症男性的精浆 Cd 水平明显高于正常精液量男性。应告知患者有毒金属可能产生的不良影响。
