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Stuck in a Moment: Does Abnormal Persistence of Epithelial Progenitors Drive Pulmonary Fibrosis?

作者信息

Auyeung Vincent C, Sheppard Dean

机构信息

Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine University of California, San Francisco San Francisco, California.

出版信息

Am J Respir Crit Care Med. 2021 Mar 15;203(6):667-669. doi: 10.1164/rccm.202010-3898ED.

DOI:10.1164/rccm.202010-3898ED
PMID:33226835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7958518/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c1/7958518/93171a701a25/rccm.202010-3898EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c1/7958518/93171a701a25/rccm.202010-3898EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c1/7958518/93171a701a25/rccm.202010-3898EDf1.jpg

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本文引用的文献

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Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis.肺泡 II 型细胞衰老导致进行性肺纤维化。
Am J Respir Crit Care Med. 2021 Mar 15;203(6):707-717. doi: 10.1164/rccm.202004-1274OC.
2
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis.单细胞 RNA 测序揭示了肺纤维化中不同上皮和间充质谱系的促纤维化作用。
Sci Adv. 2020 Jul 8;6(28):eaba1972. doi: 10.1126/sciadv.aba1972. eCollection 2020 Jul.
3
Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration.
急性呼吸窘迫综合征的临床和机制异质性的新见解:2021 年阿斯彭肺会议总结。
Am J Respir Cell Mol Biol. 2022 Sep;67(3):284-308. doi: 10.1165/rcmb.2022-0089WS.
4
IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis.IRE1α 驱动肺上皮祖细胞功能障碍,为肺纤维化建立龛位。
Am J Physiol Lung Cell Mol Physiol. 2022 Apr 1;322(4):L564-L580. doi: 10.1152/ajplung.00408.2021. Epub 2022 Feb 16.
5
Irreversibility of Pulmonary Fibrosis.肺纤维化的不可逆性
Aging Dis. 2022 Feb 1;13(1):73-86. doi: 10.14336/AD.2021.0730. eCollection 2022 Feb.
6
Lung Injury and Repair in Coronavirus Disease 2019-Related Acute Lung Injury.2019冠状病毒病相关急性肺损伤中的肺损伤与修复
Am J Pathol. 2022 Mar;192(3):406-409. doi: 10.1016/j.ajpath.2022.01.001. Epub 2022 Jan 11.
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4
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis.通过 Krt8+过渡性干细胞状态实现肺泡再生,该状态在人类肺纤维化中持续存在。
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5
Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis.肺纤维化中与再生相关的过渡性肺泡上皮细胞状态的持续存在。
Nat Cell Biol. 2020 Aug;22(8):934-946. doi: 10.1038/s41556-020-0542-8. Epub 2020 Jul 13.
6
Ineffectual Type 2-to-Type 1 Alveolar Epithelial Cell Differentiation in Idiopathic Pulmonary Fibrosis: Persistence of the KRT8 Transitional State.特发性肺纤维化中2型至1型肺泡上皮细胞分化无效:KRT8过渡状态的持续存在。
Am J Respir Crit Care Med. 2020 Jun 1;201(11):1443-1447. doi: 10.1164/rccm.201909-1726LE.
7
Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration.气道上皮干细胞存在于 club 细胞中,但可被动员以促进肺泡再生。
Cell Stem Cell. 2020 Mar 5;26(3):346-358.e4. doi: 10.1016/j.stem.2019.12.014. Epub 2020 Jan 23.
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Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.单核细胞来源的肺泡巨噬细胞驱动肺纤维化,并在整个生命周期中持续存在于肺中。
J Exp Med. 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10.
9
Identification of an atypical monocyte and committed progenitor involved in fibrosis.鉴定一种参与纤维化的非典型单核细胞和定向祖细胞。
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10
Forging a signature of in vivo senescence.伪造体内衰老的签名。
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