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人类健康与蜗牛。

Human health and snails.

机构信息

Department of Environmental Sciences, Central University of Himachal Pradesh, DharamshalaDharamshala, India.

School of Chemical Sciences, Central University of Haryana, Mahendragarh, Haryana, India.

出版信息

J Immunoassay Immunochem. 2021 May 4;42(3):211-235. doi: 10.1080/15321819.2020.1844751. Epub 2020 Nov 23.

DOI:10.1080/15321819.2020.1844751
PMID:33226881
Abstract

Snails can provide a considerable variety of bioactive compounds for cosmetic and pharmaceutical industries, useful for the development of new formulations with less toxicity and post effects compared to regular compounds used for the purpose. Compounds from crude extract, mucus, slime consist of glycans, polypeptides, proteins, etc., and can be used for curing diseases like viral lesions, warts, and different dermal problems. Some particular uses of snails involve treating post-traumatic stress. Micro RNA of , was known to be responsible for the development of long-term memory and treatment of Alzheimer's and Dementia like diseases. This review explores the application of various bioactive compounds from snails with its potential as new translational medicinal and cosmetic applications. Snail bioactive compounds like ω-MVIIA, μ-SIIIA, μO-MrVIB, Xen2174, δ-EVIA, α-Vc1.1, σ-GVIIA, Conantokin-G, and Contulakin-G, conopeptides can be used for the development of anti-cancer drugs. These compounds target the innate immunity and improve the defense system of humans and provide protection against these life-threatening health concerns.FDA: Food and Drug Administration; UTI: urinal tract infection; nAChRs: nicotinic acetylcholine receptors; NMDA: N-methyl-D-aspartate; CNS: central nervous system; CAR T: chimeric antigen receptors therapy; Micro RNA: micro ribonucleic acid.

摘要

蜗牛可以为化妆品和制药行业提供大量的生物活性化合物,这些化合物在开发新配方方面具有很大的潜力,与常规用于该目的的化合物相比,其毒性和后期效果更小。从粗提取物、黏液、黏液中提取的化合物包括糖、多肽、蛋白质等,可以用于治疗病毒损伤、疣和不同的皮肤问题等疾病。蜗牛的一些特殊用途包括治疗创伤后应激。Micro RNA of ,被认为是负责长期记忆的发展和治疗阿尔茨海默病和痴呆症等疾病。本综述探讨了各种来自蜗牛的生物活性化合物的应用及其作为新的转化医学和化妆品应用的潜力。蜗牛的生物活性化合物,如 ω-MVIIA、μ-SIIIA、μO-MrVIB、Xen2174、δ-EVIA、α-Vc1.1、σ-GVIIA、Conantokin-G 和 Contulakin-G,是可以用于开发抗癌药物的 conopeptides。这些化合物靶向先天免疫,增强人类的防御系统,为人类提供针对这些危及生命的健康问题的保护。FDA:食品和药物管理局;UTI:尿路感染;nAChRs:烟碱型乙酰胆碱受体;NMDA:N-甲基-D-天冬氨酸;CNS:中枢神经系统;CAR T:嵌合抗原受体疗法;Micro RNA:微核糖核酸。

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Human health and snails.人类健康与蜗牛。
J Immunoassay Immunochem. 2021 May 4;42(3):211-235. doi: 10.1080/15321819.2020.1844751. Epub 2020 Nov 23.
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