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亚美尼亚结核病控制中的差距:如何改进护理系统?

Gaps in tuberculosis control in Armenia: How to improve the care system?

机构信息

Tuberculosis Research and Prevention Center NGO, Yerevan, Armenia.

Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization (WHO), Geneva, Switzerland.

出版信息

J Infect Dev Ctries. 2020 Nov 16;14(11.1):133S-139S. doi: 10.3855/jidc.11911.

Abstract

INTRODUCTION

Tuberculosis (TB) continues to be a global public health problem. People with weakened immune systems are more vulnerable to TB. It is one of the top 10 causes of death worldwide and is a leading cause of death for people living with HIV (PLWH). The aim of the current study was to perform programmatic data analysis of TB cases treated with the first-line drugs, registered in Armenia for the period of January 2017 - August 2018, and to identify gaps in TB care system in Armenia.

METHODOLOGY

A retrospective cohort study using programmatic data from National TB Program.

RESULTS

Overall treatment success rate for the period of study was 79%. HIV had impact only on "died" outcome with odds ratio (OR) of 20.9. More than a third (34%) of all HIV-positive patients died during TB treatment and 45% of patients who had non-Armenian citizenship were lost to follow-up during the treatment (OR = 3.3). Treatment duration for the 8% of all cases (mainly with brain or bone localization) was > 9 months and lasted up to 500 days.

CONCLUSIONS

Better collaboration and partial integration of TB and HIV services in Armenia is required. The access to care for non-Armenian citizens needs to be improved. The national TB treatment guideline needs to be updated based on scientific evidence. This study demonstrates that continuous analysis of the available data and tailoring of the system is required to address the needs of key populations and achieve universal care coverage.

摘要

简介

结核病(TB)仍然是一个全球性的公共卫生问题。免疫系统较弱的人更容易感染结核病。它是全球十大死因之一,也是艾滋病毒(PLWH)感染者的主要死因之一。本研究的目的是对 2017 年 1 月至 2018 年 8 月期间在亚美尼亚用一线药物治疗的结核病病例进行方案数据分析,并确定亚美尼亚结核病护理系统中的差距。

方法

这是一项使用国家结核病规划方案数据进行的回顾性队列研究。

结果

研究期间的总体治疗成功率为 79%。HIV 仅对“死亡”结局有影响,比值比(OR)为 20.9。超过三分之一(34%)的所有 HIV 阳性患者在结核病治疗期间死亡,45%的非亚美尼亚公民在治疗期间失访(OR = 3.3)。所有病例的 8%(主要为脑或骨定位)的治疗时间超过 9 个月,最长达 500 天。

结论

亚美尼亚需要更好地协作,并将结核病和艾滋病服务部分整合。需要改善非亚美尼亚公民的护理机会。国家结核病治疗指南需要根据科学证据进行更新。本研究表明,需要持续分析现有数据并调整系统,以满足重点人群的需求并实现普及保健覆盖。

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