伊朗儿童耐甲氧西林金黄色葡萄球菌的患病率：一项系统评价和荟萃分析。
Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis.
作者信息
Sarrafzadeh Farhad, Sohrevardi Seyed Mojtaba, Abousaidi Hamid, Mirzaei Hossein
机构信息
Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Pharmaceutical Science Research Center, Faculty of pharmacy, Shahid Sadoughi University of Medical Science, Yazd, Iran.
出版信息
Clin Exp Pediatr. 2021 Aug;64(8):415-421. doi: 10.3345/cep.2020.00255. Epub 2020 Nov 20.
BACKGROUND
Antibiotic resistance is associated with longer hospitalizations, higher treatment costs, and increased morbidity and mortality rates.
PURPOSE
This study aimed to determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in Iranian children.
METHODS
International databases, including Web of Science, PubMed, Embase, and Scopus, and Iranian databases, including Scientific Information Database (www.sid.ir), Magiran, and Iranian Database for Medical Literature (idml.research.ac.ir), were systematically searched for articles published between January 2000 and August 2019. Sources of heterogeneity were determined using subgroup analysis and meta-regression.
RESULTS
Overall, 343 studies were identified; of them, 20 were included in the meta-analysis to estimate the pooled prevalence. The pooled prevalence of MRSA was 42% (95% confidence interval [CI], 29-55) among culture-positive cases of S. aureus, 51% (95% CI, 39-62) in hospitalized children, and 14% (95% CI, 0.05-27) in healthy children.
CONCLUSION
The overall pooled prevalence of MRSA in children was 42%. Appropriate infection control measures and effective antibiotic therapy are needed.
背景
抗生素耐药性与住院时间延长、治疗费用增加以及发病率和死亡率上升有关。
目的
本研究旨在确定伊朗儿童中耐甲氧西林金黄色葡萄球菌（MRSA）的流行情况。
方法
系统检索国际数据库，包括科学引文索引、医学期刊数据库、荷兰医学文摘数据库和Scopus数据库，以及伊朗数据库，包括科学信息数据库（www.sid.ir）、Magiran数据库和伊朗医学文献数据库（idml.research.ac.ir），以查找2000年1月至2019年8月发表的文章。使用亚组分析和meta回归确定异质性来源。
结果
共识别出343项研究；其中，20项纳入meta分析以估计合并患病率。在金黄色葡萄球菌培养阳性病例中，MRSA的合并患病率为42%（95%置信区间[CI]，29 - 55），住院儿童中为51%（95%CI，39 - 62），健康儿童中为14%（95%CI，0.05 - 27）。
结论
儿童中MRSA的总体合并患病率为42%。需要采取适当的感染控制措施和有效的抗生素治疗。
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