Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Professorate Innovative Molecular Diagnostics, Faculty of Science & Technology, University of Applied Sciences, Leiden, The Netherlands.
J Glob Antimicrob Resist. 2018 Mar;12:202-206. doi: 10.1016/j.jgar.2017.10.015. Epub 2017 Oct 28.
Methicillin-resistant Staphylococcus aureus (MRSA) is considered a major cause of infection and mortality in burn patients, especially when nosocomially acquired. However, limited information is available on the prevalence of MRSA among burn patients in Iran.
A systematic search was performed using different electronic databases including Medline (via PubMed), Embase, Web of Science and Iranian Database. A meta-analysis was performed using Comprehensive Meta-Analysis Software (BioStat v.2.2). Use of a fixed- or random-effects model was used based on a heterogeneity test, and publication bias was assessed using Begg rank correlation and Egger weighted regression methods.
Of 555 articles published from January 2000 to January 2016, 13 studies were included in this review. The meta-analyses showed that the prevalence of MRSA infection in burn patients was 77.9% (95% confidence interval 70.2-84.0%) among culture-positive cases.
The results of this study indicate that the prevalence of MRSA among burn patients is very high in Iran. Thus, a comprehensive infection control strategy based on hand hygiene, education and training in antibiotic prescribing, environmental cleaning, contact precautions, good antibiotic stewardship and an active surveillance system on the basis of international criteria is urgently needed.
耐甲氧西林金黄色葡萄球菌（MRSA）被认为是烧伤患者感染和死亡的主要原因，尤其是在医院获得性感染时。然而，关于伊朗烧伤患者中 MRSA 的流行情况，相关信息有限。
使用不同的电子数据库（包括 Medline（通过 PubMed）、Embase、Web of Science 和伊朗数据库）进行系统检索。使用 Comprehensive Meta-Analysis Software（BioStat v.2.2）进行荟萃分析。根据异质性检验，使用固定效应或随机效应模型，并使用 Begg 等级相关和 Egger 加权回归方法评估发表偏倚。
在 2000 年 1 月至 2016 年 1 月期间发表的 555 篇文章中，有 13 项研究纳入了本综述。荟萃分析结果显示，在培养阳性病例中，烧伤患者 MRSA 感染的患病率为 77.9%（95%置信区间为 70.2%至 84.0%）。
本研究结果表明，MRSA 在伊朗烧伤患者中的流行率非常高。因此，迫切需要基于手卫生、抗生素处方教育和培训、环境清洁、接触预防、良好的抗生素管理以及基于国际标准的主动监测系统的综合感染控制策略。
