Centre for Drug Research, Universiti Sains Malaysia, 11800, Gelugor, Penang, Malaysia.
Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany.
Behav Brain Res. 2021 Feb 5;399:113021. doi: 10.1016/j.bbr.2020.113021. Epub 2020 Nov 20.
Kratom is a medicinal plant that exhibits promising results as an opiate substitute. However, there is little information regarding the abuse profile of its main psychoactive constituent, mitragynine (MG), particularly in relapse to drug abuse. Using the place conditioning procedure as a model of relapse, this study aims to evaluate the ability of MG to induce conditioned place preference (CPP) reinstatement in rats. To evaluate the cross-reinstatement effects, MG and morphine were injected to rats that previously extinguished a morphine- or MG-induced CPP. Following a CPP acquisition induced by either MG (10 and 30 mg/kg, i.p.) or morphine (10 mg/kg, i.p.), rats were subjected to repeated CPP extinction sessions. A low dose priming injection of MG or morphine produced a reinstatement of the previously extinguished CPP. In the second experiment of this study, a priming injection of morphine (1, 3 and 10 mg/kg, i.p.) dose-dependently reinstated an MG-induced CPP. Likewise, a priming injection of MG (3, 10 and 30 mg/kg, i.p.) was able to dose-dependently reinstate a morphine-induced CPP. The present study demonstrates a cross-reinstatement effect between MG and morphine, thereby suggesting a similar interaction in their rewarding motivational properties. The findings from this study also suggesting that a priming exposure to kratom and an opioid may cause relapse for a previously abused drug.
标题： Kratom（咔特）：一种有前景的阿片类药物替代品
摘要：咔特是一种药用植物，作为阿片类药物的替代品具有很好的应用前景。然而，关于其主要精神活性成分（即帽柱木碱，mitragynine，MG）的滥用情况，目前所知甚少，尤其是在药物滥用复发方面。本研究采用位置条件反射程序作为药物滥用复发的模型，旨在评估 MG 诱导大鼠条件性位置偏爱（CPP）复吸的能力。为了评估交叉复吸效应，将 MG 和吗啡注射到先前已经消除了吗啡或 MG 诱导的 CPP 的大鼠体内。MG（10 和 30mg/kg，腹腔注射）或吗啡（10mg/kg，腹腔注射）诱导 CPP 获得后，对大鼠进行多次 CPP 消退训练。MG 或吗啡的低剂量引发剂量依赖性复吸，从而使先前消除的 CPP 重新出现。在本研究的第二项实验中，吗啡（1、3 和 10mg/kg，腹腔注射）的引发剂量依赖性复吸了 MG 诱导的 CPP。同样，MG（3、10 和 30mg/kg，腹腔注射）也能够剂量依赖性复吸吗啡诱导的 CPP。本研究表明 MG 和吗啡之间存在交叉复吸效应，这表明它们在奖赏动机特性方面存在相似的相互作用。研究结果还表明，咔特和阿片类药物的初次暴露可能导致先前滥用药物的复发。
