**植物硷**：从暴露在美沙冬里的涡虫获得的线索。
Kratom pharmacology: Clues from planarians exposed to mitragynine.
机构信息
Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA; Department of Pharmacology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, Philadelphia, PA, 19140, USA.
出版信息
Physiol Behav. 2021 Oct 1;239:113499. doi: 10.1016/j.physbeh.2021.113499. Epub 2021 Jun 17.
Mitragynine (MG), the most prevalent bioactive alkaloid in kratom, displays nanomolar affinity for µ, κ and δ opioid receptors and produces opioid-dependent antinociception and dependence in rats. Here, using a battery of behavioral assays, we investigated MG effects in planarians. Acute MG exposure (< 100 μM) did not affect planarian motility or environmental preference, but reduced motility was detected during abstinence from chronic MG (1, 10 μM). MG (10 μM) produced place conditioning effects that were reduced by naltrexone (10 μΜ). These results suggest that MG produces opioid-sensitive reinforcing effects in planarians and MG pharmacology is conserved across different species.
美拉诺因（MG）是一种存在于恰特草中的生物活性生物碱，对μ、κ和δ阿片受体具有纳摩尔亲和力，并在大鼠中产生阿片类依赖的镇痛和依赖性。在这里，我们使用一系列行为检测方法，研究了 MG 在扁形动物中的作用。急性 MG 暴露（<100 μM）不会影响扁形动物的运动性或环境偏好，但在慢性 MG（1、10 μM）戒断期间检测到运动性降低。MG（10 μM）产生了位置条件作用，这种作用被纳曲酮（10 μM）所减弱。这些结果表明，MG 在扁形动物中产生了阿片类敏感的强化作用，并且 MG 药理学在不同物种中是保守的。
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