Rosenstock J, Strowig S, Cercone S, Raskin P
University of Texas Health Science Center, Dallas 75235.
Diabetes Care. 1987 Nov-Dec;10(6):729-34. doi: 10.2337/diacare.10.6.729.
We measured plasma lipid and lipoprotein levels at baseline and at 6-mo intervals in 47 normolipidemic patients with classic insulin-dependent diabetes mellitus treated either with a conventional (n = 21) or intensive (n = 26) diabetes-treatment program. Patients were followed for a mean of 3 yr (range 1-4 yr). Intensive diabetes treatment resulted in a significant improvement in glycemic control that caused sustained changes in plasma lipid and lipoprotein levels that were not evident with the conventional-treatment program. These changes, which persisted for periods averaging 3 yr, can potentially reduce predicted risk for the development of premature atherosclerosis. Thus, long-term near normoglycemia may have a role in the prevention of atherosclerosis in insulin-dependent diabetic patients.
我们对47名血脂正常的典型胰岛素依赖型糖尿病患者进行了研究，这些患者接受传统（n = 21）或强化（n = 26）糖尿病治疗方案，在基线时以及每隔6个月测量血浆脂质和脂蛋白水平。患者平均随访3年（范围1 - 4年）。强化糖尿病治疗使血糖控制得到显著改善，导致血浆脂质和脂蛋白水平持续变化，而传统治疗方案则未出现这种明显变化。这些变化平均持续3年，可能会降低预测的过早发生动脉粥样硬化的风险。因此，长期接近正常血糖水平可能在胰岛素依赖型糖尿病患者预防动脉粥样硬化方面发挥作用。
