Sosenko J M, Breslow J L, Miettinen O S, Gabbay K H
N Engl J Med. 1980 Mar 20;302(12):650-4. doi: 10.1056/NEJM198003203021202.
We explored the relation of plasma lipid levels to the degree of blood glucose control in young, insulin-dependent diabetic patients. Levels of total plasma cholesterol and triglyceride, of their lipoprotein subfractions, and of hemoglobin A, and fasting blood glucose were measured repeatedly over a one-year period in 105 patients. Lipid levels were also measured in 74 nondiabetic siblings. Increasingly poor control of diabetes, reflected by levels of hemoglobin A1 or of fasting blood glucose, was associated with statistically significant increases in total cholesterol (P less than or equal to 0.01), total triglyceride (P less than or equal to 0.007), and lipoprotein subfractions except for high-density lipoprotein cholesterol. Diabetic patients in best control had lipid levels similar to those in their nondiabetic siblings. These data on the relation of plasma lipid levels to diabetic control lend credence to the hypothesis that poor control of blood glucose is conducive to accelerated atherosclerosis in diabetes mellitus.
我们探讨了血浆脂质水平与年轻的胰岛素依赖型糖尿病患者血糖控制程度之间的关系。在105名患者中，对血浆总胆固醇和甘油三酯水平、其脂蛋白亚组分水平、糖化血红蛋白A1以及空腹血糖进行了为期一年的多次测量。还对74名非糖尿病患者的兄弟姐妹进行了脂质水平测量。糖化血红蛋白A1或空腹血糖水平反映出糖尿病控制越来越差，这与总胆固醇（P≤0.01）、总甘油三酯（P≤0.007）以及除高密度脂蛋白胆固醇外的脂蛋白亚组分的统计学显著增加相关。血糖控制最佳的糖尿病患者的脂质水平与他们非糖尿病的兄弟姐妹相似。这些关于血浆脂质水平与糖尿病控制关系的数据支持了血糖控制不佳有利于糖尿病患者动脉粥样硬化加速的假说。
