School of Mental Health, Wenzhou Medical University, Wenzhou, China.
School of First Clinical Medical, Wenzhou Medical University, Wenzhou, China.
J Psychosom Res. 2021 Jan;140:110295. doi: 10.1016/j.jpsychores.2020.110295. Epub 2020 Nov 13.
Postpartum depression (PPD) has received increasing attention due to its harmful impacts and high incidence. PPD is affected by physiological and psychological factors, but the conclusions are not uniform at present, so this study explored the risk factors of postpartum depressive symptoms (PPDS) in Chinese population.
A total of 397 women attending the obstetric department of the First Affiliated Hospital of Wenzhou Medical University participated in the questionnaire survey, mainly through a cross sectional study. At 6 weeks postpartum, the Edinburgh Postpartum Depression Scale (EPDS) and Pittsburgh Sleep Quality Index (PSQI) were used to assess PPDS and sleep quality, respectively.
The incidence of probable PPDS in our study population was 14.6% at 6 weeks postpartum. Women with blood group A had an almost 3-fold greater risk of PPDS than those with blood group B (OR [95% CI], 2.99 [1.43-6.28], p = 0.004). After adjusting for potential confounding variables, the blood group A phenotype was significantly more prevalent in women with PPDS compared to blood group B (OR [95% CI], 2.65 [1.23-5.70], p = 0.01).
Compared to women with blood groups B, AB or O, women with blood group A had high odds of PPDS. If this result can be demonstrated and replicated in other populations, blood group A may be a useful predictor of risk for PPDS in Chinese postpartum women.
产后抑郁症（PPD）因其危害和高发病率而受到越来越多的关注。PPD 受到生理和心理因素的影响，但目前的结论并不一致，因此本研究探讨了中国人群产后抑郁症状（PPDS）的风险因素。
共有 397 名温州医科大学第一附属医院妇产科就诊的妇女参加了问卷调查，主要采用横断面研究。产后 6 周时，使用爱丁堡产后抑郁量表（EPDS）和匹兹堡睡眠质量指数（PSQI）分别评估 PPDS 和睡眠质量。
本研究人群产后 6 周时，可能发生的 PPDS 发生率为 14.6%。与血型为 B 的女性相比，血型为 A 的女性发生 PPDS 的风险几乎增加了 3 倍（OR[95%CI]，2.99[1.43-6.28]，p=0.004）。在校正了潜在的混杂变量后，与血型为 B 的女性相比，血型为 A 的女性发生 PPDS 的比例明显更高（OR[95%CI]，2.65[1.23-5.70]，p=0.01）。
与血型为 B、AB 或 O 的女性相比，血型为 A 的女性发生 PPDS 的可能性更高。如果这一结果能够在其他人群中得到证明和复制，那么血型 A 可能是中国产后妇女发生 PPDS 的一个有用的风险预测因子。
