Wozniak Jessie E, Chande Aroon T, Burd Eileen M, Band Victor I, Satola Sarah W, Farley Monica M, Jacob Jesse T, Jordan I King, Weiss David S
Emory Vaccine Center, Atlanta, GA 30317, USA.
School of Medicine, Emory University, Atlanta, GA 30322, USA.
Antibiotics (Basel). 2020 Nov 19;9(11):825. doi: 10.3390/antibiotics9110825.
Colistin is an important last-line antibiotic to treat highly resistant infections. Resistance to colistin has emerged among clinical isolates but has been associated with a significant growth defect. Here, we describe a clinical isolate with a deletion of , a regulator of colistin resistance, leading to high-level resistance in the absence of a growth defect. The identification of a path to resistance unrestrained by growth defects suggests colistin resistance could become more common in .
黏菌素是治疗高度耐药感染的一种重要的最后一线抗生素。临床分离株中已出现对黏菌素的耐药性，但这与显著的生长缺陷有关。在此，我们描述了一株临床分离株，其缺失了黏菌素耐药性调节因子 ，导致在无生长缺陷的情况下出现高水平耐药性。一条不受生长缺陷限制的耐药途径的发现表明，黏菌素耐药性在 可能会变得更加普遍。
