González-Sancho José Manuel, Larriba María Jesús, Muñoz Alberto
Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, 28029 Madrid, Spain.
Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, Spain.
Cancers (Basel). 2020 Nov 19;12(11):3434. doi: 10.3390/cancers12113434.
Abnormal activation of the Wnt/β-catenin pathway is common in many types of solid cancers. Likewise, a large proportion of cancer patients have vitamin D deficiency. In line with these observations, Wnt/β-catenin signaling and 1α,25-dihydroxyvitamin D (1,25(OH)D), the active vitamin D metabolite, usually have opposite effects on cancer cell proliferation and phenotype. In recent years, an increasing number of studies performed in a variety of cancer types have revealed a complex crosstalk between Wnt/β-catenin signaling and 1,25(OH)D. Here we review the mechanisms by which 1,25(OH)D inhibits Wnt/β-catenin signaling and, conversely, how the activated Wnt/β-catenin pathway may abrogate vitamin D action. The available data suggest that interaction between Wnt/β-catenin signaling and the vitamin D system is at the crossroads in solid cancers and may have therapeutic applications.
Wnt/β-连环蛋白信号通路的异常激活在多种实体癌中很常见。同样，很大一部分癌症患者存在维生素D缺乏。与这些观察结果一致，Wnt/β-连环蛋白信号传导与活性维生素D代谢产物1α,25-二羟基维生素D（1,25(OH)D）通常对癌细胞增殖和表型具有相反的作用。近年来，在多种癌症类型中进行的越来越多的研究揭示了Wnt/β-连环蛋白信号传导与1,25(OH)D之间复杂 的相互作用。在这里，我们综述了1,25(OH)D抑制Wnt/β-连环蛋白信号传导的机制，以及相反情况下，激活的Wnt/β-连环蛋白通路如何消除维生素D的作用。现有数据表明，Wnt/β-连环蛋白信号传导与维生素D系统之间的相互作用处于实体癌的十字路口，可能具有治疗应用价值。
