Unit of Virology, Department of Animal Health, Experimental Zooprophylactic Institute of Southern Italy, Via Salute 2, 80055 Portici, Italy.
Section of Vibo Valentia, Experimental Zooprophylactic Institute of Southern Italy, Contrada Piano di Bruno, 89852 Mileto, Italy.
Viruses. 2020 Nov 19;12(11):1331. doi: 10.3390/v12111331.
An outbreak of winter dysentery, complicated by severe respiratory syndrome, occurred in January 2020 in a high production dairy cow herd located in a hilly area of the Calabria region. Of the 52 animals belonging to the farm, 5 (9.6%) died with severe respiratory distress, death occurring 3-4 days after the appearance of the respiratory signs (caught and gasping breath). Microbiological analysis revealed absence of pathogenic bacteria whilst Real-time PCR identified the presence of RNA from Bovine Coronavirus (BCoV) in several organs: lungs, small intestine (jejunum), mediastinal lymph nodes, liver and placenta. BCoV was therefore hypothesized to play a role in the lethal pulmonary infection. Like the other CoVs, BCoV is able to cause different syndromes. Its role in calf diarrhea and in mild respiratory disease is well known: we report instead the involvement of this virus in a severe and fatal respiratory disorder, with symptoms and disease evolution resembling those of Severe Acute Respiratory Syndromes (SARS).
2020 年 1 月，在卡拉布里亚地区丘陵地区的一个高产奶牛场发生了冬季痢疾爆发，伴有严重的呼吸道综合征。该农场共有 52 头动物，其中 5 头（9.6%）因严重呼吸困难而死亡，死亡发生在出现呼吸道症状（被抓住和喘气）后 3-4 天。微生物分析显示没有致病性细菌，而实时 PCR 则在多个器官中检测到牛冠状病毒（BCoV）的 RNA：肺、小肠（空肠）、纵隔淋巴结、肝和胎盘。因此，假设 BCoV 在致死性肺感染中起作用。与其他冠状病毒一样，BCoV 能够引起不同的综合征。它在犊牛腹泻和轻度呼吸道疾病中的作用是众所周知的：我们报告的是该病毒参与严重和致命的呼吸道疾病，其症状和疾病演变类似于严重急性呼吸综合征（SARS）。
