Nishimura T, Sada M, Sasaki H, Yutani C, Hayashi M, Amemiya H, Fujita T, Akutsu T, Manabe H
Department of Radiology, National Cardiovascular Center, Osaka, Japan.
Eur J Nucl Med. 1987;13(7):343-7. doi: 10.1007/BF00252992.
It is important in heart transplantation to evaluate precisely the extent and location of cardiac rejection. At present, right ventricular endomyocardial biopsy has been used as the gold standard, however, establishment of noninvasive, simple, and easy diagnostic procedure is desired. The canine donor heart, in which atrial septal defect and tricuspid regurgitation had been produced beforehand, was heterotopically transplanted into the recipient's chest cavity. In seven dogs, two to three mCi of 111In-antimyosin was injected intravenously upon cardiac rejection before the heart was excised. 111In-antimyosin myocardial imaging was then performed using a gamma camera. In the same slice, a histopathological rejection score was calculated and divided into mild, moderate or severe injection. The uptake of 111In-antimyosin was significantly higher in moderate and severe rejected myocardium, since this agent produced a specific and selective localization and concentration in areas of myocardial damage. Therefore, this new technique allows the evaluation of therapeutic intervention upon cardiac rejection and may replace right ventricular endomyocardial biopsy.
在心脏移植中，精确评估心脏排斥反应的程度和位置非常重要。目前，右心室心内膜活检已被用作金标准，然而，人们期望建立一种无创、简单且易于操作的诊断方法。预先制造了房间隔缺损和三尖瓣反流的犬供体心脏被异位移植到受体的胸腔内。在七只狗身上，在心脏切除前出现心脏排斥反应时，静脉注射2至3毫居里的111铟抗肌凝蛋白。然后使用γ相机进行111铟抗肌凝蛋白心肌显像。在同一切片中，计算组织病理学排斥评分并分为轻度、中度或重度。111铟抗肌凝蛋白在中度和重度排斥心肌中的摄取明显更高，因为该试剂在心肌损伤区域产生了特异性和选择性定位及聚集。因此，这项新技术能够评估针对心脏排斥反应的治疗干预，并且可能取代右心室心内膜活检。
