Novitzky D, Boniaszczuk J, Cooper D K, Isaacs S, Rose A G, Smith J A, Uys C J, Barnard C N, Fraser R
S Afr Med J. 1984 Jan 7;65(1):5-7.
Radionuclide scanning of the donor left ventricle using technetium-99m-labelled red cells was used to monitor acute rejection after heterotopic heart transplantation and compared with histopathological evidence of rejection obtained at examination of an endomyocardial biopsy specimen. The ejection fraction and end-diastolic, end-systolic and stroke volumes were calculated at each examination; an equation was derived from these data to predict the degree of acute rejection, using histopathological examination of endomyocardial biopsy specimens as criteria of the presence and severity of rejection. A highly significant multiple correlation between radionuclide scanning parameters and endomyocardial biopsy was found. The advantages of non-invasive radionuclide scanning over the invasive procedure of endomyocardial biopsy are discussed.
利用锝-99m标记红细胞对供体左心室进行放射性核素扫描，以监测异位心脏移植后的急性排斥反应，并与心内膜活检标本检查时获得的排斥反应组织病理学证据进行比较。每次检查时计算射血分数、舒张末期、收缩末期和每搏输出量；根据这些数据推导出一个方程，以心内膜活检标本的组织病理学检查作为排斥反应存在和严重程度的标准，来预测急性排斥反应的程度。发现放射性核素扫描参数与心内膜活检之间存在高度显著的多重相关性。讨论了非侵入性放射性核素扫描相对于侵入性心内膜活检程序的优势。
