Kirik Melya Pelin, Pehlivan Mustafa, Nursal Ayse Feyda, Oyaci Yasemin, Pehlivan Sacide, Serin Istemi
Department of Hematology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
Department of Medical Genetics, Faculty of Medicine, Hitit University, Corum, Turkey.
BMC Res Notes. 2020 Nov 23;13(1):545. doi: 10.1186/s13104-020-05392-9.
Multiple myeloma (MM) arises from malignant plasma cells as a single clone in the bone marrow. Accumulating evidences have reported that there is an association between miR-196a2 (rs11614913) variant and various cancers while there were unverified and inconsistent results in MM. The goal of this study is to investigate the impact of the miR-196a2 variant on clinical findings and susceptibility in MM. Two hundred MM patients (156 patients under transplantation of autologous stem cell) and 200 healthy controls included in this study.
The statistical analysis showed no significant relationship for allele and frequencies of miR-196a2 genotype between patients and controls (p > 0.05). Log-rank test showed that gender has highly significant impact on both OS and PFS (p = 0.027, p = 0.045). In the univariate analysis, TT genotype (p = 0.022), and CT/TT (p = 0.008) had better OS. In the multivariate analysis, CC/CT-TT were associated with positively OS (p = 0.041). Currently, the most valuable prognostic markers in MM that has clinical implication are genetic abnormalities. It can be concluded from the results that miR-1962a variant is effective in prognosis of the MM. It is believed that these findings will help us understand the molecular basis of disease.
多发性骨髓瘤（MM）起源于骨髓中单个克隆的恶性浆细胞。越来越多的证据表明，miR-196a2（rs11614913）变体与多种癌症之间存在关联，而在MM中结果尚未得到验证且不一致。本研究的目的是探讨miR-196a2变体对MM临床结果和易感性的影响。本研究纳入了200例MM患者（156例接受自体干细胞移植）和200例健康对照。
统计分析显示，患者与对照之间miR-196a2基因型的等位基因和频率无显著关系（p>0.05）。对数秩检验显示，性别对总生存期（OS）和无进展生存期（PFS）均有高度显著影响（p = 0.027，p = 0.045）。单因素分析中，TT基因型（p = 0.022）和CT/TT（p = 0.008）的OS较好。多因素分析中，CC/CT-TT与OS呈正相关（p = 0.041）。目前，MM中具有临床意义的最有价值的预后标志物是基因异常。从结果可以得出结论，miR-1962a变体对MM的预后有效。相信这些发现将有助于我们理解疾病的分子基础。
