酿酒酵母中的嘌呤代谢。

Purine metabolism in Saccharomyces cerevisiae.

作者信息

Burridge P W, Woods R A, Henderson J F

出版信息

Can J Biochem. 1977 Sep;55(9):935-41. doi: 10.1139/o77-140.

Abstract

The synthesis, interconversion, and catabolism of purine bases, ribonucleosides, and ribonucleotides in wild-type Saccharomyces cerevisiae were studied by measuring the conversion of radioactive adenine, hypoxanthine, guanine, and glycine into acid-soluble purine bases, ribonucleosides, and ribonucleotides, and into nucleic acid adenine and guanine. The pathway(s) by which adenine is converted to inosinate is (are) uncertain. Guanine is extensively deaminated to xanthine. In addition, some guanine is converted to inosinate and adenine nucleotides. Inosinate formed either from hypoxanthine or de novo is readily converted to adenine and guanine nucleotides.

摘要

通过测量放射性腺嘌呤、次黄嘌呤、鸟嘌呤和甘氨酸向酸溶性嘌呤碱、核糖核苷和核糖核苷酸以及核酸腺嘌呤和鸟嘌呤的转化，研究了野生型酿酒酵母中嘌呤碱、核糖核苷和核糖核苷酸的合成、相互转化及分解代谢。腺嘌呤转化为肌苷酸的途径尚不确定。鸟嘌呤大量脱氨生成黄嘌呤。此外，一些鸟嘌呤转化为肌苷酸和腺嘌呤核苷酸。由次黄嘌呤或从头合成形成的肌苷酸很容易转化为腺嘌呤和鸟嘌呤核苷酸。