非甾体抗炎药：综述。在牛和马过敏反应中的新应用。
Nonsteroidal anti-inflammatory drugs: a review. New applications in hypersensitivity reactions of cattle and horses.
作者信息
Chand N, Eyre P
出版信息
Can J Comp Med. 1977 Jul;41(3):233-40.
Nonsteroidal anti-inflammatory drugs inhibit the biosynthesis of kinins and prostaglandins and stabilize leukocyte lysosomal membranes. Nonsteroidal anti-inflammatory drugs also weakly block the biosynthesis of histamine and serotonin, and pharmacologically antagonize kinins, prostaglandins and slow-reacting substance of anaphylaxis. Nonsteroidal anti-inflammatory drugs effectively control both cardiovascular and respiratory manifestations of hypersensitivity in cattle and horses. This, coupled with the contrasting lack of effectiveness of "antiamine" drugs, suggests that bio-amines such as histamine and serotonin (5-hydroxytryptamine) may be less important than kinins, postaglandins and slow-reacting substance in the mediation of the hypersensitivity/inflammatory reaction, at least in cardiopulmonary systems of these species. Nonsteroidal anti-inflammatory drugs justify more prominence in the clinical control of acute respiratory disease in domestic herbivores.
非甾体抗炎药抑制激肽和前列腺素的生物合成，并稳定白细胞溶酶体膜。非甾体抗炎药还能微弱地阻断组胺和5-羟色胺的生物合成，并在药理学上拮抗激肽、前列腺素和过敏反应迟缓反应物质。非甾体抗炎药能有效控制牛和马超敏反应的心血管和呼吸系统表现。这一点，再加上“抗胺”药物明显缺乏疗效，表明在介导超敏反应/炎症反应中，组胺和5-羟色胺等生物胺的重要性可能低于激肽、前列腺素和迟缓反应物质，至少在这些物种的心肺系统中是这样。非甾体抗炎药在控制家畜急性呼吸道疾病的临床应用中更应受到重视。
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