Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche, Italy.
Department of Veterinary Sciences, University of Turin, Italy.
Prev Vet Med. 2020 Dec;185:105201. doi: 10.1016/j.prevetmed.2020.105201. Epub 2020 Nov 6.
Canine testicular tumors account for about 90 % of tumors affecting the male genitalia. Seminomas (SEM), Sertoli cell tumors (SCT), and interstitial cell tumors (ICT) are the most common histological diagnoses, but their incidence shows high variability among studies. Our aim is to report the results on the analysis of testicular tumors recorded by the population-based Umbria Canine Cancer Registry (CCR) for a 5-year time period and to assess the value of tumor major diameter, measured during trimming, in discriminating neoplastic from non-neoplastic lesions. The study was conducted on 388 testicular tumors (on 1969 total male tumors) diagnosed in 355 dogs from 2014 to 2018. The median incidence was 35 cases/100,000 dogs, with a proportion equal to 19,7 % of all tumors. The incidence on neutered male dogs was 352/100,000. Most tumors were ICTs (50 %), with fewer SEMs and SCTs (29 % and 17 %, respectively). Only 3 % of tumors were mixed germ cell-sex cord-stromal tumors (MGC-SCST). Ten percent of cases had multiple tumors in the same testicle, with SEM-ICT being prevalent (69.2 %). Tumors in cryptorchid testes were 5.9 % of the total, mostly SCT (60.9 %). Mean age at diagnosis was 10.7 ± 2.7, with similar values for different tumor types. Significant incidence ratios (IRR) were found in Golden retriever (IRR 7.18, CI95 % 4.72-10.92) and in English cocker spaniel (IRR 2.30, CI95 % 1.28-4.13) when compared with mixed breed dogs. A value of 0.3 cm (major diameter) of lesions at the moment of trimming was helpful in discriminating a final tumor histological diagnosis from a non-tumor lesion. Since the number of tumors included in this evaluation was limited, further studies to confirm the diagnostic value of this measure are recommended. Our results provided information on the incidence of canine testicular tumors in Umbria region that can be compared with future results and incidence from other geographical areas if provided with reliable data on the total population, can offer solid information on the incidence and proportion of different tumor types in specific territories, contributing also to the supervision of its inhabitants' health. Moreover, pathological data such as the major diameter of tumors can be obtained and contribute to diagnostic routine and standardization.
犬睾丸肿瘤约占影响男性生殖器官肿瘤的 90%。精原细胞瘤（SEM）、支持细胞瘤（SCT）和间质细胞瘤（ICT）是最常见的组织学诊断，但它们的发病率在不同的研究中差异很大。我们的目的是报告 5 年内乌比利亚犬癌登记处（CCR）记录的睾丸肿瘤分析结果，并评估在修剪过程中测量的肿瘤最大直径在区分肿瘤与非肿瘤病变方面的价值。该研究对 2014 年至 2018 年间 355 只雄性犬的 388 个睾丸肿瘤（共 1969 个雄性肿瘤）进行了分析。中位发病率为 35 例/10 万只犬，占所有肿瘤的比例为 19.7%。去势雄性犬的发病率为 352/100,000 只。大多数肿瘤是 ICT（50%），SEM 和 SCT 较少（分别为 29%和 17%）。只有 3%的肿瘤是混合生殖细胞-性索-基质肿瘤（MGC-SCST）。10%的病例在同一睾丸中存在多个肿瘤，以 SEM-ICT 为主（69.2%）。隐睾睾丸肿瘤占总数的 5.9%，主要是 SCT（60.9%）。诊断时的平均年龄为 10.7±2.7 岁，不同肿瘤类型的年龄相似。与混合品种犬相比，金毛猎犬（IRR 7.18，95%CI95%4.72-10.92）和英国可卡犬（IRR 2.30，95%CI95%1.28-4.13）的发病率比值（IRR）显著升高。修剪时病变的 0.3cm（最大直径）值有助于将最终的肿瘤组织学诊断与非肿瘤病变区分开来。由于本次评估中包含的肿瘤数量有限，建议进一步研究以确认该测量方法的诊断价值。我们的研究结果提供了乌比利亚地区犬睾丸肿瘤发病率的信息，如果提供了可靠的总人口数据，这些信息可以与未来的结果和其他地理区域的发病率进行比较，为特定地区不同肿瘤类型的发病率和比例提供可靠信息，为居民健康监测做出贡献。此外，还可以获得肿瘤最大直径等病理数据，有助于诊断常规和标准化。
