Hayes H M, Pendergrass T W
Int J Cancer. 1976 Oct 15;18(4):482-7. doi: 10.1002/ijc.2910180413.
Histologically confirmed testicular tumors were diagnosed in 410 dogs from 12 North American veterinary university hospitals and clinics. Three tumor-cell types, Sertoli cell tumor, interstitial cell tumor and seminoma, were about equally represented. Several breeds were identified with high risk for different testicular tumor-cell types. Cytogenetic and immunogenetic studies of these dog families could offer leads applicable to familial testicular cancer in man. The multiplicity of breeds within the series suggests that, as in man, other factors, in addition to hereditary, play a role in etiology. Cryptorchid dogs appear to have a 13.6 times higher risk of testicular tumor than normal dogs. Additionally, male dogs with an inguinal hernia have an increased risk (4.7) of testis tumors. There were no detectable excesses of other urogenital anomalies or urogenital tumors among the series. The Shetland Sheepdog is suggested as an appropriate model for research into the mechanisms responsible for testicular maldescent and tumorigenesis.
来自12家北美兽医大学医院和诊所的410只犬被诊断患有经组织学确诊的睾丸肿瘤。三种肿瘤细胞类型，即支持细胞瘤、间质细胞瘤和精原细胞瘤，所占比例大致相同。已确定几个品种的犬对于不同类型的睾丸肿瘤细胞具有高风险。对这些犬类家族进行细胞遗传学和免疫遗传学研究可能会为人类家族性睾丸癌提供适用的线索。该系列中品种的多样性表明，与人类一样，除遗传因素外，其他因素在病因学中也起作用。隐睾犬患睾丸肿瘤的风险似乎比正常犬高13.6倍。此外，患有腹股沟疝的公犬患睾丸肿瘤的风险增加（4.7倍）。该系列中未检测到其他泌尿生殖系统异常或泌尿生殖系统肿瘤的过量情况。设得兰牧羊犬被认为是研究睾丸下降异常和肿瘤发生机制的合适模型。
