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Targeting chronic and evolving neuroinflammation following traumatic brain injury to improve long-term outcomes: insights from microglial-depletion models.

作者信息

Henry Rebecca J, Loane David J

机构信息

Department of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD, USA.

Department of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD, USA; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.

出版信息

Neural Regen Res. 2021 May;16(5):976-977. doi: 10.4103/1673-5374.297068.

DOI:10.4103/1673-5374.297068
PMID:33229740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8178770/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6177/8178770/0275f0c3b824/NRR-16-976-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6177/8178770/0275f0c3b824/NRR-16-976-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6177/8178770/0275f0c3b824/NRR-16-976-g001.jpg

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Cell. 2020 Mar 5;180(5):833-846.e16. doi: 10.1016/j.cell.2020.02.013.
2
Microglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental Traumatic Brain Injury Reduces Neurodegeneration and Neurological Deficits.实验性创伤性脑损伤慢性期使用 CSF1R 抑制剂耗竭小胶质细胞可减少神经退行性变和神经功能缺损。
J Neurosci. 2020 Apr 1;40(14):2960-2974. doi: 10.1523/JNEUROSCI.2402-19.2020. Epub 2020 Feb 24.
3
Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.
Diffuse Traumatic Brain Injury Induced Stimulator of Interferons (STING) Signaling in Microglia Drives Cortical Neuroinflammation, Neuronal Dysfunction, and Impaired Cognition.
弥漫性创伤性脑损伤诱导小胶质细胞中干扰素基因刺激蛋白（STING）信号传导，驱动皮质神经炎症、神经元功能障碍和认知障碍。
Res Sq. 2025 Feb 17:rs.3.rs-5960640. doi: 10.21203/rs.3.rs-5960640/v1.
4
PPARγ activation ameliorates cognitive impairment and chronic microglial activation in the aftermath of r-mTBI.过表达过氧化物酶体增殖物激活受体γ可改善创伤性脑损伤后认知障碍和慢性小胶质细胞激活。
J Neuroinflammation. 2024 Aug 3;21(1):194. doi: 10.1186/s12974-024-03173-w.
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Profiling the neuroimmune cascade in 3xTg-AD mice exposed to successive mild traumatic brain injuries.在连续轻度创伤性脑损伤暴露下的 3xTg-AD 小鼠中描绘神经免疫级联反应。
J Neuroinflammation. 2024 Jun 13;21(1):156. doi: 10.1186/s12974-024-03128-1.
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Colony-Stimulating Factor-1 Receptor Inhibition Transiently Attenuated the Peripheral Immune Response to Experimental Traumatic Brain Injury.集落刺激因子-1受体抑制可短暂减弱对实验性创伤性脑损伤的外周免疫反应。
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J Neurotrauma. 2020 Jan 1;37(1):43-54. doi: 10.1089/neu.2019.6460. Epub 2019 Sep 18.
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Depletion of microglia immediately following traumatic brain injury in the pediatric rat: Implications for cellular and behavioral pathology.创伤性脑损伤后即刻小胶质细胞耗竭：对细胞和行为病理学的影响。
Exp Neurol. 2019 Jun;316:39-51. doi: 10.1016/j.expneurol.2019.04.004. Epub 2019 Apr 10.
6
Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation.创伤性脑损伤引起的感觉皮层神经元损伤导致杆状小胶质细胞的形成，促进星形胶质细胞增生和持续的神经炎症。
Glia. 2018 Dec;66(12):2719-2736. doi: 10.1002/glia.23523. Epub 2018 Oct 30.
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Enforced microglial depletion and repopulation as a promising strategy for the treatment of neurological disorders.强制小胶质细胞耗竭和再定植作为治疗神经退行性疾病的一种有前途的策略。
Glia. 2019 Feb;67(2):217-231. doi: 10.1002/glia.23529. Epub 2018 Oct 30.
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Nat Rev Neurol. 2017 Mar;13(3):171-191. doi: 10.1038/nrneurol.2017.13. Epub 2017 Feb 10.
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Nat Commun. 2016 May 3;7:11499. doi: 10.1038/ncomms11499.
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