• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Genetics provides new individualized therapeutic targets for Parkinson's disease.遗传学为帕金森病提供了新的个体化治疗靶点。
Neural Regen Res. 2021 May;16(5):994-995. doi: 10.4103/1673-5374.297076.
2
Advancing Personalized Medicine in Common Forms of Parkinson's Disease through Genetics: Current Therapeutics and the Future of Individualized Management.通过遗传学推进常见帕金森病形式的个性化医学：当前疗法与个体化管理的未来
J Pers Med. 2021 Mar 1;11(3):169. doi: 10.3390/jpm11030169.
3
How close are we to individualized medicine for Parkinson's disease?我们距离帕金森病的个性化医疗还有多远？
Expert Rev Neurother. 2016 Jul;16(7):815-30. doi: 10.1080/14737175.2016.1182021. Epub 2016 May 9.
4
Expression characteristics of peripheral blood genes reveal potential biomarkers and candidate therapeutic targets for Parkinson's disease.外周血基因表达特征揭示帕金森病的潜在生物标志物和候选治疗靶点。
Cell Mol Biol (Noisy-le-grand). 2020 May 15;66(2):118-124.
5
Therapeutic effects of intensive inpatient rehabilitation in advanced Parkinson's disease.晚期帕金森病患者住院强化康复治疗的疗效
Neurol Clin Neurosci. 2017 Jan;5(1):18-21. doi: 10.1111/ncn3.12088. Epub 2016 Sep 5.
6
Parkinson's disease: piecing together a genetic jigsaw.帕金森病：拼凑基因拼图
Brain. 2003 Aug;126(Pt 8):1722-33. doi: 10.1093/brain/awg172. Epub 2003 May 21.
7
Changing the research criteria for the diagnosis of Parkinson's disease: obstacles and opportunities.改变帕金森病诊断的研究标准：障碍与机遇。
Lancet Neurol. 2013 May;12(5):514-24. doi: 10.1016/S1474-4422(13)70047-4. Epub 2013 Apr 11.
8
Organoid and pluripotent stem cells in Parkinson's disease modeling: an expert view on their value to drug discovery.类器官和多能干细胞在帕金森病模型中的应用：专家对其在药物发现中的价值的看法。
Expert Opin Drug Discov. 2020 Apr;15(4):427-441. doi: 10.1080/17460441.2020.1703671. Epub 2020 Jan 3.
9
An update on potential therapeutic strategies for Parkinson's disease based on pathogenic mechanisms.基于致病机制的帕金森病潜在治疗策略的最新进展。
Expert Rev Neurother. 2016 Jun;16(6):711-22. doi: 10.1080/14737175.2016.1179112. Epub 2016 May 6.
10
Apolipoprotein E genotype in familial Parkinson's disease. The French Parkinson's Disease Genetics Study Group.家族性帕金森病中的载脂蛋白E基因型。法国帕金森病遗传学研究小组。
J Neurol Neurosurg Psychiatry. 1997 Sep;63(3):394-5.

引用本文的文献

1
Direct Neuronal Reprogramming: Bridging the Gap Between Basic Science and Clinical Application.直接神经元重编程：弥合基础科学与临床应用之间的差距
Front Cell Dev Biol. 2021 Jul 5;9:681087. doi: 10.3389/fcell.2021.681087. eCollection 2021.

本文引用的文献

1
Glucocerebrosidase Defects as a Major Risk Factor for Parkinson's Disease.葡萄糖脑苷脂酶缺陷是帕金森病的主要危险因素。
Front Aging Neurosci. 2020 Apr 21;12:97. doi: 10.3389/fnagi.2020.00097. eCollection 2020.
2
Variants in saposin D domain of prosaposin gene linked to Parkinson's disease.载脂蛋白 D 结构域基因变异与帕金森病相关。
Brain. 2020 Apr 1;143(4):1190-1205. doi: 10.1093/brain/awaa064.
3
Glucocerebrosidase as a therapeutic target for Parkinson's disease.葡萄糖脑苷脂酶作为帕金森病的治疗靶点。
Expert Opin Ther Targets. 2020 Apr;24(4):287-294. doi: 10.1080/14728222.2020.1733970. Epub 2020 Feb 27.
4
Genetics of Parkinson's disease: An introspection of its journey towards precision medicine.帕金森病的遗传学：对精准医学之旅的反思。
Neurobiol Dis. 2020 Apr;137:104782. doi: 10.1016/j.nbd.2020.104782. Epub 2020 Jan 25.
5
Glucocerebrosidase and its relevance to Parkinson disease.葡萄糖脑苷脂酶及其与帕金森病的关系。
Mol Neurodegener. 2019 Aug 29;14(1):36. doi: 10.1186/s13024-019-0336-2.
6
Glucocerebrosidase mutations and phenoconversion of REM sleep behavior disorder to parkinsonism and dementia.葡萄糖脑苷脂酶突变与 REM 睡眠行为障碍向帕金森病及痴呆的表型转化。
Parkinsonism Relat Disord. 2019 Aug;65:230-233. doi: 10.1016/j.parkreldis.2019.04.016. Epub 2019 Apr 27.
7
Glucocerebrosidase mutations and synucleinopathies: Toward a model of precision medicine.葡萄糖脑苷脂酶突变与突触核蛋白病：迈向精准医学模式。
Mov Disord. 2019 Jan;34(1):9-21. doi: 10.1002/mds.27583. Epub 2018 Dec 27.
8
Exploring genetic modifiers of Gaucher disease: The next horizon.探索戈谢病的遗传修饰因子：下一个前沿。
Hum Mutat. 2018 Dec;39(12):1739-1751. doi: 10.1002/humu.23611. Epub 2018 Sep 11.
9
Fetal gene therapy for neurodegenerative disease of infants.婴儿神经退行性疾病的胎儿基因治疗。
Nat Med. 2018 Sep;24(9):1317-1323. doi: 10.1038/s41591-018-0106-7. Epub 2018 Jul 16.
10
The role of epigenetics in lysosomal storage disorders: Uncharted territory.表观遗传学在溶酶体贮积症中的作用：未知领域。
Mol Genet Metab. 2017 Nov;122(3):10-18. doi: 10.1016/j.ymgme.2017.07.012. Epub 2017 Aug 1.

Genetics provides new individualized therapeutic targets for Parkinson's disease.

作者信息

Garcia Eric Joshua, Sidransky Ellen

机构信息

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

出版信息

Neural Regen Res. 2021 May;16(5):994-995. doi: 10.4103/1673-5374.297076.

DOI:10.4103/1673-5374.297076
PMID:33229749
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8178788/
Abstract
摘要