Genetics provides new individualized therapeutic targets for Parkinson's disease.
作者信息
Garcia Eric Joshua, Sidransky Ellen
机构信息
Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
出版信息
Neural Regen Res. 2021 May;16(5):994-995. doi: 10.4103/1673-5374.297076.
Abstract
摘要
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本文引用的文献
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Glucocerebrosidase Defects as a Major Risk Factor for Parkinson's Disease.葡萄糖脑苷脂酶缺陷是帕金森病的主要危险因素。
Front Aging Neurosci. 2020 Apr 21;12:97. doi: 10.3389/fnagi.2020.00097. eCollection 2020.
2
Variants in saposin D domain of prosaposin gene linked to Parkinson's disease.载脂蛋白 D 结构域基因变异与帕金森病相关。
Brain. 2020 Apr 1;143(4):1190-1205. doi: 10.1093/brain/awaa064.
3
Glucocerebrosidase as a therapeutic target for Parkinson's disease.葡萄糖脑苷脂酶作为帕金森病的治疗靶点。
Expert Opin Ther Targets. 2020 Apr;24(4):287-294. doi: 10.1080/14728222.2020.1733970. Epub 2020 Feb 27.
4
Genetics of Parkinson's disease: An introspection of its journey towards precision medicine.帕金森病的遗传学：对精准医学之旅的反思。
Neurobiol Dis. 2020 Apr;137:104782. doi: 10.1016/j.nbd.2020.104782. Epub 2020 Jan 25.
5
Glucocerebrosidase and its relevance to Parkinson disease.葡萄糖脑苷脂酶及其与帕金森病的关系。
Mol Neurodegener. 2019 Aug 29;14(1):36. doi: 10.1186/s13024-019-0336-2.
6
Glucocerebrosidase mutations and phenoconversion of REM sleep behavior disorder to parkinsonism and dementia.葡萄糖脑苷脂酶突变与 REM 睡眠行为障碍向帕金森病及痴呆的表型转化。
Parkinsonism Relat Disord. 2019 Aug;65:230-233. doi: 10.1016/j.parkreldis.2019.04.016. Epub 2019 Apr 27.
7
Glucocerebrosidase mutations and synucleinopathies: Toward a model of precision medicine.葡萄糖脑苷脂酶突变与突触核蛋白病：迈向精准医学模式。
Mov Disord. 2019 Jan;34(1):9-21. doi: 10.1002/mds.27583. Epub 2018 Dec 27.
8
Exploring genetic modifiers of Gaucher disease: The next horizon.探索戈谢病的遗传修饰因子：下一个前沿。
Hum Mutat. 2018 Dec;39(12):1739-1751. doi: 10.1002/humu.23611. Epub 2018 Sep 11.
9
Fetal gene therapy for neurodegenerative disease of infants.婴儿神经退行性疾病的胎儿基因治疗。
Nat Med. 2018 Sep;24(9):1317-1323. doi: 10.1038/s41591-018-0106-7. Epub 2018 Jul 16.
10
The role of epigenetics in lysosomal storage disorders: Uncharted territory.表观遗传学在溶酶体贮积症中的作用：未知领域。
Mol Genet Metab. 2017 Nov;122(3):10-18. doi: 10.1016/j.ymgme.2017.07.012. Epub 2017 Aug 1.
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