The F
J Neurol Neurosurg Psychiatry. 1997 Sep;63(3):394-5.
APOE genotypes were compared in 57 cases of familial Parkinson's disease, 46 cases of sporadic Parkinson's disease, and 387 controls. The frequency of the APOE allele epsilon4 was similar in patients with Parkinson's disease and controls, but the APOE allele epsilon2, thought to be protective for dementia, was significantly more frequent in patients with sporadic Parkinson's disease than in controls. This is the first study of Parkinson's disease to include familial cases. It confirms the absence of association between the APOE allele epsilon4 and this disease.
对57例家族性帕金森病患者、46例散发性帕金森病患者和387名对照者的载脂蛋白E（APOE）基因型进行了比较。帕金森病患者和对照者中APOE ε4等位基因的频率相似，但被认为对痴呆具有保护作用的APOE ε2等位基因在散发性帕金森病患者中的频率显著高于对照者。这是第一项纳入家族性病例的帕金森病研究。它证实了APOE ε4等位基因与这种疾病之间不存在关联。
