Department of Nephrology, Dialysis, and Renal Transplantation, Sahloul University Hospital, Sousse, Tunisia.
Saudi J Kidney Dis Transpl. 2020 Sep-Oct;31(5):1125-1128. doi: 10.4103/1319-2442.301181.
Povidone-iodine is a broad-spectrum antiseptic applied topically to treat wounds and prevent their infection. Despite the apparent innocuousness of this agent, several cases of acute kidney injury (AKI) due to iodine toxicity have been reported. We report a case of severe AKI that occurred in a 32-year-old female three days after a hysteroscopy for the diagnosis of primary sterility using povidone-iodine as the local antiseptic agent. We made a clinical diagnosis of tubular necrosis related to iodine toxicity in view of the clinical presentation and high blood iodine concentration. The patient was treated with hemodialysis until urine output and renal function improved. Physicians must be aware of the possible nephrotoxicity secondary to povidone-iodine use. Patients receiving povidone-iodine, especially those who already suffer from kidney failure, should be closely monitored. The discontinuation of this agent, with the use of hemodialysis, is usually effective.
聚维酮碘是一种广谱消毒剂，局部应用于治疗伤口并预防感染。尽管这种药物看起来无害，但已有几例因碘中毒导致的急性肾损伤 (AKI) 病例报告。我们报告了一例严重 AKI 病例，该患者为 32 岁女性，因原发性不孕行宫腔镜检查，使用聚维酮碘作为局部消毒剂，在检查后三天发生。鉴于临床表现和高碘血浓度，我们临床诊断为与碘毒性相关的肾小管坏死。该患者接受血液透析治疗，直至尿量和肾功能改善。医生必须意识到聚维酮碘使用可能导致的肾毒性。接受聚维酮碘治疗的患者，尤其是已经患有肾衰竭的患者，应密切监测。停用该药物并使用血液透析通常是有效的。
