Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo, 153-8505, Japan.
Anal Sci. 2021 Mar 10;37(3):525-528. doi: 10.2116/analsci.20SCN02. Epub 2020 Nov 20.
We investigated a host-guest complex between cucurbit[7]uril and malachite green, and its effect on the toxicity to human liver cells. The host-guest complexation was evaluated by a UV/vis titration and electrospray-ionization mass spectrometry. Interestingly, the host-guest complex resulted in remarkable suppression of the toxicity of malachite green in its practical concentration range (ca. ∼6 μM). This study is one step forward to the active control of the biological effects of potent toxicants utilizing host-guest chemistry.
我们研究了葫芦[7]脲与孔雀石绿之间的主客体配合物及其对人肝细胞毒性的影响。通过紫外/可见滴定和电喷雾电离质谱评估了主客体络合作用。有趣的是，在实际浓度范围内（约 6 μM），主客体复合物显著抑制了孔雀石绿的毒性。这项研究朝着利用主客体化学主动控制强毒性物质的生物学效应迈出了一步。
