胸腺生成素32 - 34（TP3）对苏拉明诱导的豚鼠迟发型超敏反应抑制作用的影响。

The effect of thymopoietin 32-34 (TP3) on suramin-induced inhibition on delayed type hypersensitivity in guinea pigs.

作者信息

Dénes L, Hajós G, Szporny L, Szende B, Lapis K, Sipka S, Szegedi G

机构信息

Chemical Works of Gedeon Richter Ltd., Pharmacological Research Centre, Budapest, Hungary.

出版信息

Immunol Invest. 1987 Jun;16(4):275-9. doi: 10.3109/08820138709087083.

DOI:10.3109/08820138709087083

PMID:3323037

Abstract

Suramin administration inhibits virus replication and produces impaired immunoregulation. Delayed type hypersensitivity (DTH)-reaction was inhibited by Suramin (200 mg/kg, i.p.) injection in guinea-pigs immunized with BCG vaccine. Suramin-inhibited DTH-reaction was restored to normal level after 4 days of treatment with thymopoietin 32-34 (TP 3) and TP5 (1 mg/kg, i.p.), TP3 greater than TP5. TP3 produced the strongest restoration when applied together with Suramin, but a single treatment with TP3 or TP5 oligopeptide inhibited the development of DTH-reaction. TP3 with Suramin treatment might be advantageous to eliminate defective side effects of Suramin on immune system and TP3 with indirect inducing action on IL-2, IFN-gamma production may be useful in therapy of AIDS patients.

摘要

苏拉明给药可抑制病毒复制并导致免疫调节受损。在用卡介苗疫苗免疫的豚鼠中，腹腔注射苏拉明（200mg/kg）可抑制迟发型超敏反应（DTH）。在用胸腺生成素32 - 34（TP 3）和TP5（1mg/kg，腹腔注射）治疗4天后，苏拉明抑制的DTH反应恢复到正常水平，TP 3的效果优于TP5。当与苏拉明联合应用时，TP 3产生的恢复作用最强，但单独使用TP 3或TP5寡肽会抑制DTH反应的发展。苏拉明与TP 3联合治疗可能有利于消除苏拉明对免疫系统的不良副作用，并且对白细胞介素 - 2、γ干扰素产生具有间接诱导作用的TP 3可能对艾滋病患者的治疗有用。