INSERM UA10, Department of Pediatric Radiology, Hôpital Necker Enfants Malades, AP-HP, Imagine Institute (UMR 1163), Paris Descartes University, Sorbonne Paris Cité University, Paris 75015, France.
Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives (CNRS UMR 5293), Université de Bordeaux, Bordeaux 33000, France.
Cereb Cortex. 2021 Feb 5;31(3):1776-1785. doi: 10.1093/cercor/bhaa325.
The first year of life is a key period of brain development, characterized by dramatic structural and functional modifications. Here, we measured rest cerebral blood flow (CBF) modifications throughout babies' first year of life using arterial spin labeling magnetic resonance imaging sequence in 52 infants, from 3 to 12 months of age. Overall, global rest CBF significantly increased during this age span. In addition, we found marked regional differences in local functional brain maturation. While primary sensorimotor cortices and insula showed early maturation, temporal and prefrontal region presented great rest CBF increase across the first year of life. Moreover, we highlighted a late and remarkably synchronous maturation of the prefrontal and posterior superior temporal cortices. These different patterns of regional cortical rest CBF modifications reflect a timetable of local functional brain maturation and are consistent with baby's cognitive development within the first year of life.
生命的第一年是大脑发育的关键时期，其特征是结构和功能的显著变化。在这里，我们使用动脉自旋标记磁共振成像序列在 52 名婴儿中测量了他们生命的第一年中大脑静息血流（CBF）的变化，这些婴儿的年龄在 3 到 12 个月之间。总的来说，在这段时间内，全球静息 CBF 显著增加。此外，我们发现局部功能性大脑成熟存在明显的区域差异。虽然主要的感觉运动皮质和脑岛表现出早期成熟，但颞叶和前额叶区域在整个生命的第一年中表现出了巨大的静息 CBF 增加。此外，我们还强调了前额叶和后上颞叶皮质的后期和显著同步的成熟。这些不同的区域性皮质静息 CBF 变化模式反映了局部功能大脑成熟的时间表，与婴儿在生命的第一年中的认知发展一致。
