Pilo B, Mehan S P
Department of Zoology, Faculty of Science, M.S. University of Baroda.
Indian J Physiol Pharmacol. 1987 Jul-Sep;31(3):159-69.
Insulin and acetylcholine (ACh) are both known to promote glucose uptake by liver of birds. Acetylcholine induced glucose uptake can be predictably potentiated by inhibiting acetylcholinesterase activity. Monocrotophos, acothione (organophosphorus compound) and prostigmine are known inhibitors of acetylcholinesterase (AChE). In the present study the action of these three inhibitors of AChE alone as well as in combination with insulin and acetylcholine on in vitro glucose uptake by pigeon liver slices was investigated. Both organophorus compounds potentiated the action of insulin as well as acetycholine mediated glucose uptake by liver slices while prostigmine had inhibitory influence. The three compounds also induced alterations in enzyme activities in the liver slices. These results are discussed in detail in the text.
胰岛素和乙酰胆碱（ACh）都已知可促进鸟类肝脏对葡萄糖的摄取。通过抑制乙酰胆碱酯酶活性，可以预测乙酰胆碱诱导的葡萄糖摄取会增强。久效磷、硫双威（有机磷化合物）和新斯的明是已知的乙酰胆碱酯酶（AChE）抑制剂。在本研究中，研究了这三种AChE抑制剂单独以及与胰岛素和乙酰胆碱联合对鸽肝切片体外葡萄糖摄取的作用。两种有机磷化合物都增强了胰岛素以及乙酰胆碱介导的肝切片葡萄糖摄取作用，而新斯的明则有抑制作用。这三种化合物还引起了肝切片中酶活性的改变。文中对这些结果进行了详细讨论。
