Pilo B, Mehan S P
Indian J Physiol Pharmacol. 1986 Apr-Jun;30(2):155-60.
An intrinsic hypoglycaemic activity has been attributed to ACTH. This action of ACTH is essentially mediated by increased insulin secretion. In the present study, the direct action of ACTH on glucose uptake by pigeon hepatocytes has been studied by in vitro technique. The results have shown that ACTH has a direct influence on glucose uptake and this action is not additive in presence of insulin. Glucose uptake in presence ACTH with Acetylcholine was not any more than what was obtained with ACTH alone. These observations have been taken to indicate a non-existence of synergistic action of ACTH with insulin or acetylcholine in promoting glucose uptake by avian liver cells.
促肾上腺皮质激素（ACTH）被认为具有内在的降血糖活性。ACTH的这一作用主要是通过增加胰岛素分泌来介导的。在本研究中，采用体外技术研究了ACTH对鸽肝细胞摄取葡萄糖的直接作用。结果表明，ACTH对葡萄糖摄取有直接影响，并且在有胰岛素存在时，这一作用不会叠加。ACTH与乙酰胆碱共同存在时的葡萄糖摄取量并不比单独使用ACTH时更高。这些观察结果表明，ACTH与胰岛素或乙酰胆碱在促进禽肝细胞摄取葡萄糖方面不存在协同作用。
