Hakami N, Monzon C M
Department of Child Health, University of Missouri Health Sciences Center, Columbia.
Hematol Oncol Clin North Am. 1987 Dec;1(4):567-75.
Acute nonlymphocytic leukemia (ANLL) is a heterogeneous group of hematologic malignancies caused by a clonal proliferation of primitive myeloid cells. 30 Infiltration of the bone marrow by these cells causes impairment of normal hematopoiesis and results in anemia, granulocytopenia, and thrombocytopenia. Recent progress in bone marrow culture techniques, cytogenetics, and immunology have contributed to a better understanding of the pathophysiology of ANLL. Major therapeutic advances have also occurred because of improved supportive care and carefully designed prospective and randomized clinical trials. This article presents the current knowledge of the diagnosis and management of ANLL.
急性非淋巴细胞白血病（ANLL）是一组由原始髓细胞克隆性增殖引起的异质性血液系统恶性肿瘤。这些细胞浸润骨髓会导致正常造血功能受损，进而引起贫血、粒细胞减少和血小板减少。骨髓培养技术、细胞遗传学和免疫学方面的最新进展有助于更好地理解ANLL的病理生理学。由于支持治疗的改善以及精心设计的前瞻性和随机临床试验，主要治疗也取得了进展。本文介绍了ANLL诊断和管理的当前知识。
