Meyers P A
Department of Pediatrics, Cornell University Medical College, New York, New York.
Hematol Oncol Clin North Am. 1987 Dec;1(4):667-73.
Ewing's sarcoma is a rare, malignant, small, round-cell tumor of bone. Most tumors arise in the diaphyses of long bones, but any bone can be involved. Chemotherapy is essential for long-term survival. Multiagent protocols are superior to single-agent therapies, but the ideal regimen has not been established. Both radiation therapy and surgery have been employed for local control of primary tumors. Control with either modality is significantly better when used in conjunction with effective chemotherapy. Patients who present with metastatic disease or pelvic primaries have a worse prognosis. Autologous bone marrow transplantation may improve disease-free survival for this group.
尤因肉瘤是一种罕见的、恶性的、小型圆形细胞骨肿瘤。大多数肿瘤发生于长骨骨干，但任何骨骼都可能受累。化疗对于长期生存至关重要。多药联合方案优于单药治疗，但理想的治疗方案尚未确立。放射治疗和手术均已用于原发性肿瘤的局部控制。当与有效的化疗联合使用时，这两种治疗方式的控制效果均显著更好。出现转移性疾病或骨盆原发性肿瘤的患者预后较差。自体骨髓移植可能会改善该组患者的无病生存期。
