Cancer Research Institute, Tomsk National Research Medical Center, Tomsk, Russia.
Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Bull Exp Biol Med. 2020 Nov;170(1):75-78. doi: 10.1007/s10517-020-05007-0. Epub 2020 Nov 24.
The peculiarities of gastric cancer development associated with the expression levels of components of the AKT/mTOR signaling cascade and PD, PD-L1, PD-L2 have not yet been identified. We revealed the fundamental changes in the expression AKT/mTOR and PD receptors and their ligands associated with dissemination of gastric cancer. An increase in the mRNA level of all components of this cascade was demonstrated. The expression of mTOR and AKT decreased against the background of enhanced expression of PTEN phosphatase. The increase in the expression of PD-1 receptors and PD-L1 and PD-L2 ligands was most pronounced in patients with distant metastases.
与 AKT/mTOR 信号级联和 PD、PD-L1、PD-L2 成分的表达水平相关的胃癌发展的特点尚未确定。我们揭示了与胃癌扩散相关的 AKT/mTOR 和 PD 受体及其配体表达的基本变化。证明了该级联的所有成分的 mRNA 水平增加。在增强的 PTEN 磷酸酶表达的背景下，mTOR 和 AKT 的表达减少。在有远处转移的患者中，PD-1 受体和 PD-L1 和 PD-L2 配体的表达增加最为明显。
