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[海绵体内注射血管活性药物。对其在勃起功能障碍中价值研究的贡献]

[Intracavernous injections of vasoactive drugs. Contribution to the study of their value in erectile impotence].

作者信息

Bondil P, Dorémieux J, Nguyen Qui J L

出版信息

J Urol (Paris). 1987;93(6):361-8.

PMID:3323319
Abstract

The obtention of an artificial erection with a single intracavernous injection (ICI) of vasoactive drugs, has upset our conceptions about erection and the approach for erectile failure. If this pharmacologic stimulation increases the reliability of some erection tests, their diagnosis value is still questioned. The complexity of both erection and vasomotricity pharmacology, make difficult the understanding of the mechanisms of these ICI. Their therapeutic value is reduced to the method by self injections, new treatment for impotence, even if it concerns only few impotent patients. Finally, the experimental feature and the unquestionable morbidity of these ICI, mainly priapism, impede their large diffusion. However, in spite of these doubts, this intracavernous pharmacology is a real progress for erection and its troubles.

摘要

通过海绵体内单次注射血管活性药物获得人工勃起,颠覆了我们对勃起及勃起功能障碍治疗方法的认知。尽管这种药物刺激提高了某些勃起测试的可靠性,但其诊断价值仍受到质疑。勃起药理学和血管舒缩药理学都很复杂,这使得理解海绵体内注射的作用机制变得困难。其治疗价值仅限于自我注射这种新的阳痿治疗方法,即便适用的阳痿患者数量很少。最后,海绵体内注射的试验性质以及不可忽视的发病率(主要是阴茎异常勃起)阻碍了其广泛应用。然而,尽管存在这些疑问,海绵体内药理学对于勃起及其相关问题而言仍是一项切实的进展。

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